DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: LIG_APCC_ABBAyCdc20_2

Location: 501:507

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8518

ASA_SCORE: 111

COIL: 0.8849

CONS_SCORE: 0.4111

DSS_SCORE: 0.659

HELIX: 0.0803

FCONS_SCORE: 0.9817

RIG_SCORE: 0.5866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S496I	TCGA-AD-5900	COAD	TCGA	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S496I	DO8514	COAD	ICGC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S511P	TCGA-AP-A056	UCEC	TCGA	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S511P	DO43971	UCEC	ICGC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R506Q	TCGA-BR-7851	STAD	TCGA	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R506Q	DO38711	STAD	ICGC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.6218
p.S511F	TCGA-EE-A2GL	SKCM	TCGA	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S511F	DO37434	SKCM	ICGC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R494C	TCGA-L5-A4OI	ESCA	TCGA	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S510L	TCGA-RP-A693	SKCM	TCGA	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.S510L	DO51268	SKCM	ICGC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.R506W	TCGA-YZ-A985	UVM	TCGA	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.7523
p.R494H	DO227634	COCA	ICGC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S510A	DO36556	READ	ICGC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.L491P	SIDM00282	Colorectal Carcinoma	GDSC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L491P	ACH-000998	Colon/Colorectal Cancer	CCLE	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L491P	CW-2	large_intestine	COSMIC	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.0556
p.M497I	ACH-000279	Bone Cancer	CCLE	KSSLYRE	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1R4	Transcription factor HIVEP3	LIG_APCC_ABBAyCdc20_2	501:507	KSSLYRE	APC,CDC20,FZR1	0.8518	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons