DegronMD

Uniprot ID: Q9UKX7

Source protein: Nuclear pore complex protein Nup50

Source gene: NUP50

Class: DEG_SCF_SKP2-CKS1_1

Location: 242:249

E3 ligase: SKP2,CSK1

DEGRON score: 0.9222

ASA_SCORE: 97.3375

COIL: 0.8214

CONS_SCORE: 0.349

DSS_SCORE: 0.5955

HELIX: 0.1344

FCONS_SCORE: 0.9544

RIG_SCORE: 0.7021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q232K	TCGA-DA-A1HV	SKCM	TCGA	KTEDTPDK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T235M	TCGA-EO-A22U	UCEC	TCGA	KTEDTPDK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T235M	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	KTEDTPDK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T235M	KYSE-140	oesophagus	COSMIC	KTEDTPDK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T259M	SIDM00487	Colorectal Carcinoma	GDSC	KTEDTPDK	DEG_SCF_SKP2-CKS1_1	0.5
p.T259M	ACH-000963	Colon/Colorectal Cancer	CCLE	KTEDTPDK	DEG_SCF_SKP2-CKS1_1	0.5
p.T259M	CCK-81	large_intestine	COSMIC	KTEDTPDK	DEG_SCF_SKP2-CKS1_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKX7	Nuclear pore complex protein Nup50	DEG_SCF_SKP2-CKS1_1	242:249	KTEDTPDK	SKP2,CSK1	0.9222	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons