DegronMD

Uniprot ID: Q92673

Source protein: Sortilin-related receptor

Source gene: SORL1

Class: LIG_APCC_ABBAyCdc20_2

Location: 572:578

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6601

ASA_SCORE: 63.9143

COIL: 0.3373

CONS_SCORE: 0.402

DSS_SCORE: 0.1555

HELIX: 0.0026

FCONS_SCORE: 0.7515

RIG_SCORE: 0.9309

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G585D	TCGA-BR-8361	STAD	TCGA	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G585D	TCGA-EB-A41A	SKCM	TCGA	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G585D	DO37429	SKCM	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G585D	DO48032	STAD	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T565P	TCGA-FA-A82F	DLBC	TCGA	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T565P	DO219891	DLBC	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L586I	TCGA-HU-8602	STAD	TCGA	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L586I	DO47829	STAD	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R575H	DO8400	COAD	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R575H	DO47769	STAD	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R575C	DO222755	COCA	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.8301
p.V583L	DO229031	LICA	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G576V	DO229031	LICA	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.7532
p.R575L	DO229036	LICA	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.8428
p.G578E	DO220886	MELA	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.7199
p.G578E	DO51283	SKCM	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.7199
p.G576R	DO37406	SKCM	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.7568
p.D582N	DO50288	SKCM	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.V567I	DO47833	STAD	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V567I	HCT-15	large_intestine	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.F574S	DO229272	THCA	ICGC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.6871
p.G568E	SIDM00422	Hodgkin's Lymphoma	GDSC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G568E	ACH-001203	Lymphoma	CCLE	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G568E	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.S564R	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S564R	ACH-002392	Lymphoma	CCLE	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S564R	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.I579T	ACH-002196	Lung Cancer	CCLE	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.I579T	SBC-1	lung	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D577A	HLE	liver	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.7793
p.D577A	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.7793
p.K578M	EC-GI-10	oesophagus	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.8062
p.K578M	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.8062
p.K578M	OSC-20	upper_aerodigestive_tract	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.8062
p.P570L	SNU-1040	large_intestine	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P570S	MZ7-mel	skin	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K585N	HT-115	large_intestine	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G576E	ChaGo-K-1	lung	COSMIC	KTFIFSE	LIG_APCC_ABBAyCdc20_2	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KTFIFSE

Degron related mutations and impact score

Drug responses associated with SORL1 mutations

All proteins holding degron of KTFIFSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92673	Sortilin-related receptor	LIG_APCC_ABBAyCdc20_2	572:578	KTFIFSE	APC,CDC20,FZR1	0.6601	More...