DegronMD

Uniprot ID: Q92841

Source protein: Probable ATP-dependent RNA helicase DDX17

Source gene: DDX17

Class: LIG_APCC_ABBAyCdc20_2

Location: 420:426

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7543

ASA_SCORE: 21.2714

COIL: 0.253

CONS_SCORE: 0.7042

DSS_SCORE: 0.2863

HELIX: 0.0166

FCONS_SCORE: 1.3849

RIG_SCORE: 0.9022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D432G	TCGA-AD-5900	COAD	TCGA	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T421K	TCGA-BH-A0H3	BRCA	TCGA	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.6195
p.L434P	TCGA-CM-6674	COAD	TCGA	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H427R	DO220881	MELA	ICGC	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.75
p.H427R	DO37655	SKCM	ICGC	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.75
p.H427R	DO37679	SKCM	ICGC	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.75
p.H427R	DO47712	SKCM	ICGC	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.75
p.H427R	DO51296	SKCM	ICGC	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.75
p.Y425H	DO41799	UCEC	ICGC	KTIIFVE	LIG_APCC_ABBAyCdc20_2	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92841	Probable ATP-dependent RNA helicase DDX17	LIG_APCC_ABBAyCdc20_2	420:426	KTIIFVE	APC,CDC20,FZR1	0.7543	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons