DegronMD

Uniprot ID: Q5VZ66

Source protein: Janus kinase and microtubule-interacting protein 3

Source gene: JAKMIP3

Class: LIG_APCC_ABBAyCdc20_2

Location: 76:82

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7978

ASA_SCORE: 104.4714

COIL: 0.099

CONS_SCORE: 0.9273

DSS_SCORE: 0.3549

HELIX: 0.8987

FCONS_SCORE: 1.1994

RIG_SCORE: 0.7837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R91C	TCGA-63-A5MM	LUSC	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R91C	TCGA-66-2777	LUSC	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R91C	DO219153	LUSC	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R91C	DO27516	LUSC	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T68I	TCGA-A5-A0G1	UCEC	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T68I	DO42472	UCEC	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A69V	TCGA-AA-A00N	COAD	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A69V	DO9876	COAD	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A69V	SIDM01608	Endometrial Carcinoma	GDSC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E82D	TCGA-CJ-6030	KIRC	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E82D	DO19058	KIRC	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E92K	TCGA-CR-6472	HNSC	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E92K	DO15870	HNSC	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A69T	TCGA-DX-A7EU	SARC	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A69T	DO220040	SARC	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.L87R	TCGA-EO-A3B0	UCEC	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L87R	DO219773	UCEC	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K76N	TCGA-IG-A5B8	ESCA	TCGA	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.6918
p.R91H	DO50440	ESAD	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Q88H	DO228948	LICA	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T68A	DO232224	PBCA	ICGC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A89V	SIDM00534	Colorectal Carcinoma	GDSC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A89V	ACH-000986	Colon/Colorectal Cancer	CCLE	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A89V	HT-115	large_intestine	COSMIC	KTKLHEE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZ66	Janus kinase and microtubule-interacting protein 3	LIG_APCC_ABBAyCdc20_2	76:82	KTKLHEE	APC,CDC20,FZR1	0.7978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KTKLHEE

Degron related mutations and impact score

Drug responses associated with JAKMIP3 mutations

All proteins holding degron of KTKLHEE