DegronMD

Uniprot ID: Q10472

Source protein: Polypeptide N-acetylgalactosaminyltransferase 1

Source gene: GALNT1

Class: LIG_APCC_ABBAyCdc20_2

Location: 107:113

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5177

ASA_SCORE: 84.3286

COIL: 0.7164

CONS_SCORE: 0.5638

DSS_SCORE: 0.224

HELIX: 0.0604

FCONS_SCORE: 0.7647

RIG_SCORE: 0.8079

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K107R	TCGA-AQ-A54O	BRCA	TCGA	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.6126
p.R102M	TCGA-D3-A2JD	SKCM	TCGA	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R102M	DO37543	SKCM	ICGC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P116S	TCGA-D3-A3C6	SKCM	TCGA	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.25
p.L115F	TCGA-DU-7010	LGG	TCGA	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G105R	TCGA-ZF-AA53	BLCA	TCGA	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G105R	DO219096	BLCA	ICGC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S109C	DO233103	GACA	ICGC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.7541
p.E108D	DO10880	GBM	ICGC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.6758
p.A97S	DO229027	LICA	ICGC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R105M	DO229034	LICA	ICGC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R105M	DO230965	LUSC	ICGC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P117Q	DO26454	LUSC	ICGC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G105V	SIDM00120	Prostate Carcinoma	GDSC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G105V	DU-145	prostate	COSMIC	KTKVYPD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q10472	Polypeptide N-acetylgalactosaminyltransferase 1	LIG_APCC_ABBAyCdc20_2	107:113	KTKVYPD	APC,CDC20,FZR1	0.5177	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons