DegronMD

Uniprot ID: Q6P9G4

Source protein: Transmembrane protein 154

Source gene: TMEM154

Class: LIG_APCC_ABBAyCdc20_2

Location: 130:136

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9997

ASA_SCORE: 78.3286

COIL: 0.697

CONS_SCORE: 0.9702

DSS_SCORE: 0.4706

HELIX: 0.1204

FCONS_SCORE: 1.2027

RIG_SCORE: 0.7876

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E143K	TCGA-AP-A056	UCEC	TCGA	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E143K	DO43971	UCEC	ICGC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S140F	TCGA-EE-A29M	SKCM	TCGA	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.6667
p.S140F	TCGA-FW-A3R5	SKCM	TCGA	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.6667
p.S140F	DO37406	SKCM	ICGC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.6667
p.S140F	DO37404	SKCM	ICGC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.6667
p.E123K	TCGA-Z2-A8RT	SKCM	TCGA	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E123K	DO220877	MELA	ICGC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E123K	DO51301	SKCM	ICGC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T138I	DO229003	COCA	ICGC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00304	Ovarian Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00315	Glioblastoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM01005	Acute Myeloid Leukemia	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00590	Oral Cavity Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00596	Endometrial Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00587	Biliary Tract Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00488	Colorectal Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00567	Other Solid Cancers	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00247	Gastric Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00397	Acute Myeloid Leukemia	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00988	Kidney Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00324	Neuroblastoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00986	Head and Neck Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM00316	Glioblastoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM01449	Pancreatic Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM01446	Glioblastoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM01413	Oral Cavity Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM01587	Bladder Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T138I	SIDM01619	Endometrial Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T121I	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.5278
p.T121I	SIDM00103	Mesothelioma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.5278
p.T121I	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.5278
p.T121I	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.5278
p.E145K	SIDM00679	Cervical Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E145K	ACH-001525	Cervical Cancer	CCLE	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E145K	HT-3	cervix	COSMIC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.M146L	SIDM01372	Pancreatic Carcinoma	GDSC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.M146L	ACH-000266	Pancreatic Cancer	CCLE	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E124K	HT-3	cervix	COSMIC	KVPIFEE	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KVPIFEE

Degron related mutations and impact score

Drug responses associated with TMEM154 mutations

All proteins holding degron of KVPIFEE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P9G4	Transmembrane protein 154	LIG_APCC_ABBAyCdc20_2	130:136	KVPIFEE	APC,CDC20,FZR1	0.9997	More...