DegronMD

Uniprot ID: P53801

Source protein: Pituitary tumor-transforming gene 1 protein-interacting protein

Source gene: PTTG1IP

Class: LIG_APCC_ABBAyCdc20_2

Location: 164:170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9995

ASA_SCORE: 93.0857

COIL: 0.7907

CONS_SCORE: 0.629

DSS_SCORE: 0.4196

HELIX: 0.1944

FCONS_SCORE: 1.3399

RIG_SCORE: 0.7544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T156S	TCGA-B5-A3FC	UCEC	TCGA	KYGLFKE	LIG_APCC_ABBAyCdc20_2	0.5556
p.K169N	TCGA-FD-A6TK	BLCA	TCGA	KYGLFKE	LIG_APCC_ABBAyCdc20_2	0.5806
p.M154T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	KYGLFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.M154T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	KYGLFKE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P173L	SIDM00217	Colorectal Carcinoma	GDSC	KYGLFKE	LIG_APCC_ABBAyCdc20_2	0.25
p.P173L	SNU-1040	large_intestine	COSMIC	KYGLFKE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53801	Pituitary tumor-transforming gene 1 protein-interacting protein	LIG_APCC_ABBAyCdc20_2	164:170	KYGLFKE	APC,CDC20,FZR1	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons