DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LACTPISS
Uniprot ID:
Q5VUJ5
Source protein:
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
Source gene:
AGAP7P
Class:
DEG_SCF_FBW7_1
Location:
327:334
E3 ligase:
FBXW7
DEGRON score:
0.9605
ASA_SCORE:
55.9625
COIL:
0.6941
CONS_SCORE:
0.279
DSS_SCORE:
0.3189
HELIX:
0.0506
FCONS_SCORE:
1.0272
RIG_SCORE:
0.7732
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with AGAP7P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LACTPISS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VUJ5
Putative Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 7
DEG_SCF_FBW7_1
327:334
LACTPISS
FBXW7
0.9605
More...