DegronMD

Uniprot ID: Q16665

Source protein: Hypoxia-inducible factor 1-alpha

Source gene: HIF1A

Class: DEG_ODPH_VHL_1

Location: 400:413

E3 ligase: VHL

DEGRON score: 0.9709

ASA_SCORE: 74.3571

COIL: 0.8164

CONS_SCORE: 0.7571

DSS_SCORE: 0.3503

HELIX: 0.0586

FCONS_SCORE: 1.0422

RIG_SCORE: 0.7727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D412N	TCGA-AP-A059	UCEC	TCGA	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.5821
p.S409I	TCGA-B5-A3FA	UCEC	TCGA	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.7341
p.S409I	DO52402	UCEC	ICGC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.7341
p.E403K	TCGA-D5-6928	COAD	TCGA	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.7022
p.E403K	DO7776	COAD	ICGC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.7022
p.K415R	TCGA-KS-A4IB	THCA	TCGA	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.2778
p.K415R	DO40033	THCA	ICGC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.2778
p.A397S	DO51189	LUAD	ICGC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.25
p.P423Q	DO42280	UCEC	ICGC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.0556
p.R404Q	DO42472	UCEC	ICGC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.7329
p.R404Q	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.7329
p.M393T	SIDM00870	Breast Carcinoma	GDSC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.1389
p.M393T	HCC202	breast	COSMIC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.1389
p.S406T	RL	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.7116
p.E420Q	PCI-4B	upper_aerodigestive_tract	COSMIC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.1389
p.A410V	SNU-1040	large_intestine	COSMIC	LAPAAGDTIISLDF	DEG_ODPH_VHL_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16665	Hypoxia-inducible factor 1-alpha	DEG_ODPH_VHL_1	400:413	LAPAAGDTIISLDF	VHL	0.9709	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons