DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPAPLDSDMPL
Uniprot ID:
Q03933
Source protein:
Heat shock factor protein 2
Source gene:
HSF2
Class:
DEG_ODPH_VHL_1
Location:
522:533
E3 ligase:
VHL
DEGRON score:
0.9253
ASA_SCORE:
74.5
COIL:
0.8875
CONS_SCORE:
0.2836
DSS_SCORE:
0.4072
HELIX:
0.065
FCONS_SCORE:
1.0476
RIG_SCORE:
0.7638
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P526H
TCGA-D5-6928
COAD
TCGA
LAPAPLDSDMPL
DEG_ODPH_VHL_1
0.6583
p.A525V
SIDM00660
Colorectal Carcinoma
GDSC
LAPAPLDSDMPL
DEG_ODPH_VHL_1
0.5825
p.A525V
ACH-000985
Colon/Colorectal Cancer
CCLE
LAPAPLDSDMPL
DEG_ODPH_VHL_1
0.5825
p.A525V
LS-411N
large_intestine
COSMIC
LAPAPLDSDMPL
DEG_ODPH_VHL_1
0.5825
Drug responses associated with HSF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPAPLDSDMPL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q03933
Heat shock factor protein 2
DEG_ODPH_VHL_1
522:533
LAPAPLDSDMPL
VHL
0.9253
More...