DegronMD

Uniprot ID: Q86UR1

Source protein: NADPH oxidase activator 1

Source gene: NOXA1

Class: DEG_ODPH_VHL_1

Location: 357:368

E3 ligase: VHL

DEGRON score: 0.9493

ASA_SCORE: 70.6917

COIL: 0.7841

CONS_SCORE: 0.3432

DSS_SCORE: 0.4149

HELIX: 0.0336

FCONS_SCORE: 0.9716

RIG_SCORE: 0.6981

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H364Y	TCGA-B5-A5OC	UCEC	TCGA	LAPGEDGHWVPI	DEG_ODPH_VHL_1	0.6118
p.S355P	DO227432	EOPC	ICGC	LAPGEDGHWVPI	DEG_ODPH_VHL_1	0.2778
p.V372I	DO233244	GACA	ICGC	LAPGEDGHWVPI	DEG_ODPH_VHL_1	0.2222
p.V372I	DO228376	MALY	ICGC	LAPGEDGHWVPI	DEG_ODPH_VHL_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UR1	NADPH oxidase activator 1	DEG_ODPH_VHL_1	357:368	LAPGEDGHWVPI	VHL	0.9493	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons