DegronMD

Uniprot ID: P08631

Source protein: Tyrosine-protein kinase HCK

Source gene: HCK

Class: DEG_ODPH_VHL_1

Location: 159:170

E3 ligase: VHL

DEGRON score: 0.8857

ASA_SCORE: 45.0417

COIL: 0.5843

CONS_SCORE: 0.4743

DSS_SCORE: 0.3642

HELIX: 0.0557

FCONS_SCORE: 0.8861

RIG_SCORE: 0.759

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A154S	TCGA-44-6144	LUAD	TCGA	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.1944
p.D153H	TCGA-67-3771	LUAD	TCGA	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.1667
p.M169I	TCGA-85-A50Z	LUSC	TCGA	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.6507
p.A160V	TCGA-VQ-A924	STAD	TCGA	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.6936
p.E155Q	TCGA-VS-A958	CESC	TCGA	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.2222
p.R155H	DO48369	BLCA	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.2222
p.A159T	DO222404	BTCA	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7139
p.E154Q	DO51639	CESC	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.1944
p.G161S	DO222864	COCA	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.6993
p.R155C	DO233156	GACA	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.2222
p.R155C	IGROV-1	ovary	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.2222
p.D152H	DO25797	LUAD	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.25
p.A153S	DO24190	LUAD	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.1667
p.M168I	DO45462	LUSC	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7618
p.S180F	DO47623	SKCM	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.5
p.A159V	DO51795	STAD	ICGC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.6936
p.I170M	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.6507
p.I170M	EKVX	lung	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.6507
p.R156C	SIDM00151	Ovarian Carcinoma	GDSC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.25
p.R156C	IGROV-1	ovary	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.25
p.I149M	ACH-000706	Lung Cancer	CCLE	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.0556
p.I149M	EKVX	lung	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.0556
p.R169Q	ACH-000883	Brain Cancer	CCLE	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7329
p.R169Q	SW1783	central_nervous_system	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7329
p.D167E	ACH-000921	Lung Cancer	CCLE	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.6758
p.V174M	ACH-000955	Colon/Colorectal Cancer	CCLE	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.2222
p.V174M	SNU-407	large_intestine	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.2222
p.V163M	ACH-000965	Endometrial/Uterine Cancer	CCLE	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7208
p.V163M	RL95-2	endometrium	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7208
p.V173M	SNU-407	large_intestine	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.25
p.I169M	EKVX	lung	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7618
p.R168Q	SW1783	central_nervous_system	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7329
p.V162M	RL95-2	endometrium	COSMIC	LAPGNMLGSFMI	DEG_ODPH_VHL_1	0.7208

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGNMLGSFMI

Degron related mutations and impact score

Drug responses associated with HCK mutations

All proteins holding degron of LAPGNMLGSFMI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08631	Tyrosine-protein kinase HCK	DEG_ODPH_VHL_1	159:170	LAPGNMLGSFMI	VHL	0.8857	More...