DegronMD

Uniprot ID: P06239

Source protein: Tyrosine-protein kinase Lck

Source gene: LCK

Class: DEG_ODPH_VHL_1

Location: 142:153

E3 ligase: VHL

DEGRON score: 0.7088

ASA_SCORE: 45.875

COIL: 0.5911

CONS_SCORE: 0.6978

DSS_SCORE: 0.4343

HELIX: 0.048

FCONS_SCORE: 1.0182

RIG_SCORE: 0.7057

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R134H	TCGA-KN-8437	KICH	TCGA	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.1111
p.E157K	TCGA-VS-A958	CESC	TCGA	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.2222
p.E141Q	DO2919	BRCA	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.3056
p.R147L	DO49774	KIRP	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.8428
p.D135V	DO26560	LUSC	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.25
p.L138M	DO232224	PBCA	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.2222
p.L138M	DO42568	UCEC	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.2222
p.L161M	DO37921	SKCM	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.1111
p.E154K	DO51291	SKCM	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.3056
p.S152I	DO41572	UCEC	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.7341
p.A143S	SIDM00683	Prostate Carcinoma	GDSC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.7588
p.A143S	ACH-000977	lymph_node	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.7588
p.R139Q	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.25
p.R139Q	ACH-001106	Leukemia	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.25
p.A160T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.1389
p.A160T	ACH-000981	Leukemia	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.1389
p.R154L	ACH-000901	Lung Cancer	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.3056
p.F151S	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.7982

Drug responses associated with LCK mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A353V (No)	GDSC	A-770041	0.0061
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A353V (No)	GDSC	WH-4-023	0.0051
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A353V (No)	GDSC	JW-7-24-1	0.3077
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P447L (No)	GDSC	A-770041	0.0061
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P447L (No)	GDSC	WH-4-023	0.0051
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P447L (No)	GDSC	JW-7-24-1	0.3077
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A500T (No)	GDSC	A-770041	0.0061
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A500T (No)	GDSC	WH-4-023	0.0051
SIDM00951	LAML\|acute_myeloid_leukaemia	p.A500T (No)	GDSC	JW-7-24-1	0.3077
SIDM00981	DLBC\|B_cell_lymphoma	p.G201S (No)	GDSC	A-770041	0.0438
SIDM00981	DLBC\|B_cell_lymphoma	p.G201S (No)	GDSC	WH-4-023	0.0194
SIDM00145	ALL\|lymphoblastic_leukemia	p.A289D (No)	GDSC	A-770041	5.0256
SIDM00145	ALL\|lymphoblastic_leukemia	p.A289D (No)	GDSC	WH-4-023	6.637
SIDM00145	ALL\|lymphoblastic_leukemia	p.A289D (No)	GDSC	JW-7-24-1	1.4246
SIDM00145	ALL\|lymphoblastic_leukemia	p.A396V (No)	GDSC	A-770041	5.0256
SIDM00145	ALL\|lymphoblastic_leukemia	p.A396V (No)	GDSC	WH-4-023	6.637
SIDM00145	ALL\|lymphoblastic_leukemia	p.A396V (No)	GDSC	JW-7-24-1	1.4246
SIDM01187	BRCA\|breast	p.R45Q (No)	GDSC	JW-7-24-1	7.0162
SIDM00272	BRCA\|breast	p.S377R (No)	GDSC	JW-7-24-1	4.4679
SIDM00603	HNSC\|head_and_neck	p.T416I (No)	GDSC	JW-7-24-1	11.0199
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G201S (No)	GDSC	A-770041	5.0431
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G201S (No)	GDSC	WH-4-023	40.2786
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.G201S (No)	GDSC	JW-7-24-1	2.7592
SIDM01007	ALL\|lymphoblastic_leukemia	p.G175V (No)	GDSC	A-770041	2.5863
SIDM01007	ALL\|lymphoblastic_leukemia	p.G175V (No)	GDSC	WH-4-023	2.587
SIDM01007	ALL\|lymphoblastic_leukemia	p.G175V (No)	GDSC	JW-7-24-1	1.6102
SIDM01007	ALL\|lymphoblastic_leukemia	p.A353T (No)	GDSC	A-770041	2.5863
SIDM01007	ALL\|lymphoblastic_leukemia	p.A353T (No)	GDSC	WH-4-023	2.587
SIDM01007	ALL\|lymphoblastic_leukemia	p.A353T (No)	GDSC	JW-7-24-1	1.6102
SIDM01056	BRCA\|breast	p.G201S (No)	GDSC	JW-7-24-1	5.2406
SIDM00498	COREAD\|large_intestine	p.Q328R (No)	GDSC	JW-7-24-1	36.8549
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.T87S (No)	GDSC	A-770041	8.6059
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.T87S (No)	GDSC	WH-4-023	19.0418
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.T87S (No)	GDSC	JW-7-24-1	4.428
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.S42L (No)	GDSC	A-770041	31.2626
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.S42L (No)	GDSC	WH-4-023	89.3127
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.S42L (No)	GDSC	JW-7-24-1	5.264
SIDM00217	COREAD\|large_intestine	p.R45W (No)	GDSC	JW-7-24-1	6.9819
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P232_W233insQKP (No)	GDSC	A-770041	0.0061
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P232_W233insQKP (No)	GDSC	WH-4-023	0.0051
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P232_W233insQKP (No)	GDSC	JW-7-24-1	0.3077
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G201S (No)	GDSC	A-770041	8.9468
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G201S (No)	GDSC	WH-4-023	11.3159
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G201S (No)	GDSC	JW-7-24-1	7.7579
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.R45Q (No)	GDSC	A-770041	2.6501
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.R45Q (No)	GDSC	WH-4-023	6.9666
SIDM01247	UNCLASSIFIED\|Burkitt_lymphoma	p.R45Q (No)	GDSC	JW-7-24-1	1.4554
SIDM00282	COREAD\|large_intestine	p.E467D (No)	GDSC	A-770041	146.9586
SIDM00282	COREAD\|large_intestine	p.E467D (No)	GDSC	WH-4-023	95.7608
SIDM00282	COREAD\|large_intestine	p.E467D (No)	GDSC	JW-7-24-1	7.6135
SIDM01088	UNCLASSIFIED\|endometrium	p.W339fs*16 (No)	GDSC	A-770041	0.4469
SIDM01088	UNCLASSIFIED\|endometrium	p.W339fs*16 (No)	GDSC	WH-4-023	0.9041
SIDM01088	UNCLASSIFIED\|endometrium	p.W339fs*16 (No)	GDSC	JW-7-24-1	83.8822
SIDM00150	COREAD\|large_intestine	p.R363H (No)	GDSC	A-770041	25.7274
SIDM00150	COREAD\|large_intestine	p.R363H (No)	GDSC	WH-4-023	52.8585
SIDM00150	COREAD\|large_intestine	p.R363H (No)	GDSC	JW-7-24-1	6.5728
SIDM01100	NB\|neuroblastoma	p.V167I (No)	GDSC	A-770041	17.5355
SIDM01100	NB\|neuroblastoma	p.V167I (No)	GDSC	WH-4-023	8.6424
SIDM01100	NB\|neuroblastoma	p.V167I (No)	GDSC	JW-7-24-1	12.3137
SIDM00783	COREAD\|large_intestine	p.R484W (No)	GDSC	JW-7-24-1	1.2448
SIDM00660	COREAD\|large_intestine	p.G81fs*51 (No)	GDSC	A-770041	19.936
SIDM00660	COREAD\|large_intestine	p.G81fs*51 (No)	GDSC	WH-4-023	11.4444
SIDM00660	COREAD\|large_intestine	p.G81fs*51 (No)	GDSC	JW-7-24-1	4.0629
SIDM01145	STAD\|stomach	p.R480H (No)	GDSC	A-770041	26.594
SIDM01145	STAD\|stomach	p.R480H (No)	GDSC	WH-4-023	0.415
SIDM01145	STAD\|stomach	p.R480H (No)	GDSC	JW-7-24-1	70.5035
SIDM01026	ESCA\|oesophagus	p.E448Q (No)	GDSC	JW-7-24-1	6.6543
SIDM00283	DLBC\|B_cell_lymphoma	p.V259G (No)	GDSC	A-770041	5.7846
SIDM00283	DLBC\|B_cell_lymphoma	p.V259G (No)	GDSC	WH-4-023	5.8335
SIDM00283	DLBC\|B_cell_lymphoma	p.V259G (No)	GDSC	JW-7-24-1	1.0244
SIDM00080	SKCM\|melanoma	p.V259G (No)	GDSC	JW-7-24-1	6.6228
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.S42L (No)	GDSC	JW-7-24-1	10.3223
SIDM00983	BLCA\|bladder	p.E482Q (No)	GDSC	JW-7-24-1	7.3052
SIDM00837	COREAD\|large_intestine	p.G201S (No)	GDSC	JW-7-24-1	28.4513
SIDM00728	LUAD\|lung_NSCLC_adenocarcinoma	p.G456S (No)	GDSC	JW-7-24-1	242.2574
SIDM00193	COREAD\|large_intestine	p.G5E (No)	GDSC	JW-7-24-1	8.0027
SIDM00118	COREAD\|large_intestine	p.N339S (No)	GDSC	JW-7-24-1	14.6378
SIDM00118	COREAD\|large_intestine	p.R458H (No)	GDSC	JW-7-24-1	14.6378

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGNTHGSFLI

Degron related mutations and impact score

Drug responses associated with LCK mutations

All proteins holding degron of LAPGNTHGSFLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06239	Tyrosine-protein kinase Lck	DEG_ODPH_VHL_1	142:153	LAPGNTHGSFLI	VHL	0.7088	More...