DegronMD

Uniprot ID: P06239

Source protein: Tyrosine-protein kinase Lck

Source gene: LCK

Class: DEG_ODPH_VHL_1

Location: 142:153

E3 ligase: VHL

DEGRON score: 0.7088

ASA_SCORE: 45.875

COIL: 0.5911

CONS_SCORE: 0.6978

DSS_SCORE: 0.4343

HELIX: 0.048

FCONS_SCORE: 1.0182

RIG_SCORE: 0.7057

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R147L	DO49774	KIRP	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.8428
p.F151S	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.7982
p.A143S	SIDM00683	Prostate Carcinoma	GDSC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.7588
p.A143S	ACH-000977	lymph_node	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.7588
p.S152I	DO41572	UCEC	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.7341
p.E141Q	DO2919	BRCA	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.3056
p.E154K	DO51291	SKCM	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.3056
p.R154L	ACH-000901	Lung Cancer	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.3056
p.D135V	DO26560	LUSC	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.25
p.R139Q	SIDM01034	B-Lymphoblastic Leukemia	GDSC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.25
p.R139Q	ACH-001106	Leukemia	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.25
p.E157K	TCGA-VS-A958	CESC	TCGA	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.2222
p.L138M	DO232224	PBCA	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.2222
p.L138M	DO42568	UCEC	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.2222
p.A160T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.1389
p.A160T	ACH-000981	Leukemia	CCLE	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.1389
p.R134H	TCGA-KN-8437	KICH	TCGA	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.1111
p.L161M	DO37921	SKCM	ICGC	LAPGNTHGSFLI	DEG_ODPH_VHL_1	0.1111

Showing 1 to 18 of 18 entries

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Drug responses associated with LCK mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00145	ALL\|lymphoblastic_leukemia	p.A289D (No)	GDSC	A-770041	5.0256
SIDM00145	ALL\|lymphoblastic_leukemia	p.A289D (No)	GDSC	WH-4-023	6.637
SIDM00145	ALL\|lymphoblastic_leukemia	p.A289D (No)	GDSC	JW-7-24-1	1.4246
SIDM00145	ALL\|lymphoblastic_leukemia	p.A396V (No)	GDSC	A-770041	5.0256
SIDM00145	ALL\|lymphoblastic_leukemia	p.A396V (No)	GDSC	WH-4-023	6.637
SIDM00145	ALL\|lymphoblastic_leukemia	p.A396V (No)	GDSC	JW-7-24-1	1.4246
SIDM01007	ALL\|lymphoblastic_leukemia	p.G175V (No)	GDSC	A-770041	2.5863
SIDM01007	ALL\|lymphoblastic_leukemia	p.G175V (No)	GDSC	WH-4-023	2.587
SIDM01007	ALL\|lymphoblastic_leukemia	p.G175V (No)	GDSC	JW-7-24-1	1.6102
SIDM01007	ALL\|lymphoblastic_leukemia	p.A353T (No)	GDSC	A-770041	2.5863
SIDM01007	ALL\|lymphoblastic_leukemia	p.A353T (No)	GDSC	WH-4-023	2.587
SIDM01007	ALL\|lymphoblastic_leukemia	p.A353T (No)	GDSC	JW-7-24-1	1.6102
SIDM00983	BLCA\|bladder	p.E482Q (No)	GDSC	JW-7-24-1	7.3052
SIDM01187	BRCA\|breast	p.R45Q (No)	GDSC	JW-7-24-1	7.0162
SIDM00272	BRCA\|breast	p.S377R (No)	GDSC	JW-7-24-1	4.4679
SIDM01056	BRCA\|breast	p.G201S (No)	GDSC	JW-7-24-1	5.2406
SIDM00498	COREAD\|large_intestine	p.Q328R (No)	GDSC	JW-7-24-1	36.8549
SIDM00217	COREAD\|large_intestine	p.R45W (No)	GDSC	JW-7-24-1	6.9819
SIDM00282	COREAD\|large_intestine	p.E467D (No)	GDSC	A-770041	146.9586
SIDM00282	COREAD\|large_intestine	p.E467D (No)	GDSC	WH-4-023	95.7608
SIDM00282	COREAD\|large_intestine	p.E467D (No)	GDSC	JW-7-24-1	7.6135
SIDM00150	COREAD\|large_intestine	p.R363H (No)	GDSC	A-770041	25.7274
SIDM00150	COREAD\|large_intestine	p.R363H (No)	GDSC	WH-4-023	52.8585
SIDM00150	COREAD\|large_intestine	p.R363H (No)	GDSC	JW-7-24-1	6.5728
SIDM00783	COREAD\|large_intestine	p.R484W (No)	GDSC	JW-7-24-1	1.2448

Showing 1 to 25 of 78 entries

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All proteins holding degron of LAPGNTHGSFLI

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P06239	Tyrosine-protein kinase Lck	DEG_ODPH_VHL_1	142:153	LAPGNTHGSFLI	VHL	0.7088	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPGNTHGSFLI

Degron related mutations and impact score

Drug responses associated with LCK mutations

All proteins holding degron of LAPGNTHGSFLI