DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPKRSWGTPQLRL
Uniprot ID:
A6NE52
Source protein:
WD repeat-containing protein 97
Source gene:
WDR97
Class:
DEG_ODPH_VHL_1
Location:
1422:1435
E3 ligase:
VHL
DEGRON score:
0.9419
ASA_SCORE:
87.1214
COIL:
0.6852
CONS_SCORE:
0.277
DSS_SCORE:
0.3662
HELIX:
0.2849
FCONS_SCORE:
1.0059
RIG_SCORE:
0.7446
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with WDR97 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPKRSWGTPQLRL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6NE52
WD repeat-containing protein 97
DEG_ODPH_VHL_1
1422:1435
LAPKRSWGTPQLRL
VHL
0.9419
More...