DegronMD

Uniprot ID: Q14653

Source protein: Interferon regulatory factor 3

Source gene: IRF3

Class: DEG_ODPH_VHL_1

Location: 149:162

E3 ligase: VHL

DEGRON score: 0.996

ASA_SCORE: 56.5357

COIL: 0.782

CONS_SCORE: 0.4147

DSS_SCORE: 0.6146

HELIX: 0.0606

FCONS_SCORE: 1.0277

RIG_SCORE: 0.623

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P170S	TCGA-EY-A1GQ	UCEC	TCGA	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.1111
p.P170S	ACH-001346	Head and Neck Cancer	CCLE	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.1111
p.G171E	DO2401	BRCA	ICGC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.0833
p.E151K	DO228927	COCA	ICGC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.7022
p.H142N	DO229009	LICA	ICGC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.1389
p.V149M	DO223286	UCEC	ICGC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.7208
p.R172W	SIDM02021	Esophageal Carcinoma	GDSC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.0556
p.P164S	SIDM00663	Melanoma	GDSC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.2778
p.P164S	ACH-000814	Skin Cancer	CCLE	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.2778
p.Q169R	SIDM00587	Biliary Tract Carcinoma	GDSC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.1389
p.Q169R	ACH-000778	Head and Neck Cancer	CCLE	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.1389
p.A161P	ACH-002647	Gastric Cancer	CCLE	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.6392
p.E164K	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.2778
p.G172D	NCI-H2085	lung	COSMIC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.0556
p.E153K	NCI-H1355	lung	COSMIC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.7022
p.A148V	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LAPLPDPGPPSLAV	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14653	Interferon regulatory factor 3	DEG_ODPH_VHL_1	149:162	LAPLPDPGPPSLAV	VHL	0.996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons