DegronMD

Uniprot ID: Q2PPJ7

Source protein: Ral GTPase-activating protein subunit alpha-2

Source gene: RALGAPA2

Class: DEG_ODPH_VHL_1

Location: 1485:1496

E3 ligase: VHL

DEGRON score: 0.9903

ASA_SCORE: 71.925

COIL: 0.8069

CONS_SCORE: 0.3224

DSS_SCORE: 0.3002

HELIX: 0.081

FCONS_SCORE: 0.8624

RIG_SCORE: 0.7264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1497L	TCGA-AP-A056	UCEC	TCGA	LAPNGRNPSFLI	DEG_ODPH_VHL_1	0.3056
p.S1497L	DO222884	COCA	ICGC	LAPNGRNPSFLI	DEG_ODPH_VHL_1	0.3056
p.S1497L	DO36556	READ	ICGC	LAPNGRNPSFLI	DEG_ODPH_VHL_1	0.3056
p.S1497L	DO43971	UCEC	ICGC	LAPNGRNPSFLI	DEG_ODPH_VHL_1	0.3056
p.L1481F	TCGA-D3-A2JP	SKCM	TCGA	LAPNGRNPSFLI	DEG_ODPH_VHL_1	0.2222
p.L1481F	DO47407	SKCM	ICGC	LAPNGRNPSFLI	DEG_ODPH_VHL_1	0.2222
p.H1500N	DO229041	LICA	ICGC	LAPNGRNPSFLI	DEG_ODPH_VHL_1	0.2222
p.P1487H	DO35242	PACA	ICGC	LAPNGRNPSFLI	DEG_ODPH_VHL_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2PPJ7	Ral GTPase-activating protein subunit alpha-2	DEG_ODPH_VHL_1	1485:1496	LAPNGRNPSFLI	VHL	0.9903	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons