DegronMD

Uniprot ID: A0AVI2

Source protein: Fer-1-like protein 5

Source gene: FER1L5

Class: DEG_ODPH_VHL_1

Location: 1007:1020

E3 ligase: VHL

DEGRON score: 0.744

ASA_SCORE: 74.2214

COIL: 0.6866

CONS_SCORE: 0.3415

DSS_SCORE: 0.2672

HELIX: 0.0392

FCONS_SCORE: 1.1151

RIG_SCORE: 0.7888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R999H	SIDM02035	Colorectal Carcinoma	GDSC	LAPNKDKGIAPIFL	DEG_ODPH_VHL_1	0.1111
p.L1020H	SIDM01292	Esophageal Carcinoma	GDSC	LAPNKDKGIAPIFL	DEG_ODPH_VHL_1	0.7313
p.A1009V	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	LAPNKDKGIAPIFL	DEG_ODPH_VHL_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVI2	Fer-1-like protein 5	DEG_ODPH_VHL_1	1007:1020	LAPNKDKGIAPIFL	VHL	0.744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons