DegronMD

Uniprot ID: Q14494

Source protein: Endoplasmic reticulum membrane sensor NFE2L1

Source gene: NFE2L1

Class: DEG_ODPH_VHL_1

Location: 351:363

E3 ligase: VHL

DEGRON score: 0.9754

ASA_SCORE: 74.5615

COIL: 0.8647

CONS_SCORE: 0.4454

DSS_SCORE: 0.3933

HELIX: 0.0974

FCONS_SCORE: 0.9441

RIG_SCORE: 0.7233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F362I	DO11878	GBM	ICGC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.7415
p.F362C	DO11878	GBM	ICGC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.7108
p.A358T	DO45299	LIRI	ICGC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.7139
p.P356S	SIDM00807	Bladder Carcinoma	GDSC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.5641
p.P356S	5637	urinary_tract	COSMIC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.5641
p.G369E	SIDM00655	Other Solid Cancers	GDSC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.1667
p.G369E	NCCIT	testis	COSMIC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.1667
p.A366V	SIDM01729	Endometrial Carcinoma	GDSC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.25
p.A355V	ACH-000909	Endometrial/Uterine Cancer	CCLE	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.6936
p.G358E	ACH-001578	Embryonal Cancer	CCLE	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.7199
p.G358E	NCCIT	testis	COSMIC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.7199
p.V371M	ACH-002223	Brain Cancer	CCLE	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.1111
p.V371M	D-245MG	central_nervous_system	COSMIC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.1111
p.V352M	D-245MG	central_nervous_system	COSMIC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.7208
p.L363R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LAPNTPINQNVSL	DEG_ODPH_VHL_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14494	Endoplasmic reticulum membrane sensor NFE2L1	DEG_ODPH_VHL_1	351:363	LAPNTPINQNVSL	VHL	0.9754	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons