DegronMD

Uniprot ID: Q96PE1

Source protein: Adhesion G protein-coupled receptor A2

Source gene: ADGRA2

Class: DEG_ODPH_VHL_1

Location: 633:645

E3 ligase: VHL

DEGRON score: 0.5961

ASA_SCORE: 49.1154

COIL: 0.6113

CONS_SCORE: 0.386

DSS_SCORE: 0.2149

HELIX: 0.0299

FCONS_SCORE: 0.7738

RIG_SCORE: 0.7835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V647I	SIDM00222	Mesothelioma	GDSC	LAPPVPPDCTLQL	DEG_ODPH_VHL_1	0.2778
p.V647I	SIDM00855	Other Sarcomas	GDSC	LAPPVPPDCTLQL	DEG_ODPH_VHL_1	0.2778
p.S627L	SIDM00901	Endometrial Carcinoma	GDSC	LAPPVPPDCTLQL	DEG_ODPH_VHL_1	0.1667
p.S627L	AN3-CA	endometrium	COSMIC	LAPPVPPDCTLQL	DEG_ODPH_VHL_1	0.1667
p.G637C	NCI-H1793	lung	COSMIC	LAPPVPPDCTLQL	DEG_ODPH_VHL_1	0.76
p.E646K	COLO-829	skin	COSMIC	LAPPVPPDCTLQL	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PE1	Adhesion G protein-coupled receptor A2	DEG_ODPH_VHL_1	633:645	LAPPVPPDCTLQL	VHL	0.5961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons