DegronMD

Uniprot ID: Q6F5E8

Source protein: Capping protein, Arp2/3 and myosin-I linker protein 2

Source gene: CARMIL2

Class: DEG_ODPH_VHL_1

Location: 1205:1217

E3 ligase: VHL

DEGRON score: 0.678

ASA_SCORE: 77.2

COIL: 0.4685

CONS_SCORE: 0.2601

DSS_SCORE: 0.5302

HELIX: 0.3302

FCONS_SCORE: 0.9325

RIG_SCORE: 0.7897

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1209I	SIDM00572	Gastric Carcinoma	GDSC	LAPSFEQRVQVML	DEG_ODPH_VHL_1	0.6304
p.F1209I	NUGC-3	stomach	COSMIC	LAPSFEQRVQVML	DEG_ODPH_VHL_1	0.6304
p.R1224Q	SIDM00136	Colorectal Carcinoma	GDSC	LAPSFEQRVQVML	DEG_ODPH_VHL_1	0.1389
p.R1224Q	HT-29	large_intestine	COSMIC	LAPSFEQRVQVML	DEG_ODPH_VHL_1	0.1389
p.R1200W	SIDM00214	Colorectal Carcinoma	GDSC	LAPSFEQRVQVML	DEG_ODPH_VHL_1	0.1944
p.R1200W	SNU-407	large_intestine	COSMIC	LAPSFEQRVQVML	DEG_ODPH_VHL_1	0.1944
p.Q1199E	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	LAPSFEQRVQVML	DEG_ODPH_VHL_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6F5E8	Capping protein, Arp2/3 and myosin-I linker protein 2	DEG_ODPH_VHL_1	1205:1217	LAPSFEQRVQVML	VHL	0.678	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons