DegronMD

Uniprot ID: Q13627

Source protein: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Source gene: DYRK1A

Class: DEG_ODPH_VHL_1

Location: 17:30

E3 ligase: VHL

DEGRON score: 0.9937

ASA_SCORE: 79.7571

COIL: 0.7499

CONS_SCORE: 0.3217

DSS_SCORE: 0.4391

HELIX: 0.1799

FCONS_SCORE: 1.0377

RIG_SCORE: 0.706

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H36R	TCGA-A3-3376	KIRC	TCGA	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.1667
p.H36R	DO20555	KIRC	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.1667
p.A18V	TCGA-AP-A051	UCEC	TCGA	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6936
p.A18V	DO42673	UCEC	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6936
p.R16W	TCGA-B5-A3FA	UCEC	TCGA	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.3056
p.R16W	TCGA-BH-A0HP	BRCA	TCGA	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.3056
p.R16W	DO1755	BRCA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.3056
p.R16W	DO233731	GACA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.3056
p.R16W	DO52402	UCEC	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.3056
p.M34V	TCGA-IN-A6RL	STAD	TCGA	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.2222
p.M34V	DO51738	STAD	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.2222
p.L21P	DO233898	GACA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.7582
p.D19N	DO14694	HNSC	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6932
p.A31S	DO229026	LICA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.3056
p.A26S	DO229034	LICA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6477
p.L31F	DO229038	LICA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.3056
p.L20F	DO229041	LICA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6981
p.A25S	DO229045	LICA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6477
p.Q39L	DO220878	MELA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.0833
p.R27Q	DO50732	ORCA	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.7329
p.N16K	DO38332	STAD	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.3056
p.R22K	DO41871	UCEC	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.7237
p.D19H	DO41500	UCEC	ICGC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.7688
p.S14C	SIDM00899	Pancreatic Carcinoma	GDSC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6944
p.S14C	ACH-000222	Pancreatic Cancer	CCLE	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6944
p.S14C	AsPC-1	pancreas	COSMIC	LAPSFSFHAAGLQM	DEG_ODPH_VHL_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	DEG_ODPH_VHL_1	17:30	LAPSFSFHAAGLQM	VHL	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPSFSFHAAGLQM

Degron related mutations and impact score

Drug responses associated with DYRK1A mutations

All proteins holding degron of LAPSFSFHAAGLQM