DegronMD

Uniprot ID: Q6ZS81

Source protein: WD repeat- and FYVE domain-containing protein 4

Source gene: WDFY4

Class: DEG_ODPH_VHL_1

Location: 1018:1029

E3 ligase: VHL

DEGRON score: 0.6671

ASA_SCORE: 48.975

COIL: 0.5477

CONS_SCORE: 0.4322

DSS_SCORE: 0.1428

HELIX: 0.0626

FCONS_SCORE: 1.4376

RIG_SCORE: 0.8236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1032H	TCGA-2W-A8YY	CESC	TCGA	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.25
p.Y1032H	DO223732	CESC	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.25
p.P1038Q	TCGA-AA-3984	COAD	TCGA	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.0833
p.P1038Q	DO9002	COAD	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.0833
p.S1021L	TCGA-B6-A0RU	BRCA	TCGA	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.6556
p.S1021L	TCGA-D5-6927	COAD	TCGA	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.6556
p.S1021L	DO1954	BRCA	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.6556
p.S1021L	DO10332	COAD	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.6556
p.P1013S	TCGA-DI-A1BU	UCEC	TCGA	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.1944
p.P1013S	DO42023	UCEC	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.1944
p.F1025S	TCGA-F5-6814	READ	TCGA	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.6871
p.F1025S	DO36556	READ	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.6871
p.V1029M	DO223531	CLLE	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.6097
p.A1017D	DO34272	PACA	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.3056
p.R1009C	DO32964	PACA	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.0833
p.D1028N	DO42312	UCEC	ICGC	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.6932
p.P1008S	ACH-000872	Lung Cancer	CCLE	LAPSFVEFDMSV	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZS81	WD repeat- and FYVE domain-containing protein 4	DEG_ODPH_VHL_1	1018:1029	LAPSFVEFDMSV	VHL	0.6671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons