DegronMD

Uniprot ID: Q14773

Source protein: Intercellular adhesion molecule 4

Source gene: ICAM4

Class: DEG_ODPH_VHL_1

Location: 39:52

E3 ligase: VHL

DEGRON score: 0.8722

ASA_SCORE: 62.5143

COIL: 0.6532

CONS_SCORE: 0.7612

DSS_SCORE: 0.411

HELIX: 0.0166

FCONS_SCORE: 1.3351

RIG_SCORE: 0.7091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L39F	TCGA-AC-A23H	BRCA	TCGA	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.6981
p.L39F	TCGA-EB-A41A	SKCM	TCGA	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.6981
p.L39F	DO2401	BRCA	ICGC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.6981
p.L39F	DO37429	SKCM	ICGC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.6981
p.A58T	TCGA-DM-A0XF	COAD	TCGA	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.1667
p.A58T	DO9258	COAD	ICGC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.1667
p.W49C	DO230311	COCA	ICGC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.5889
p.R51H	DO233011	GACA	ICGC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.7133
p.G36C	DO228974	LICA	ICGC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.25
p.V59L	DO229015	LICA	ICGC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.1389
p.F48L	SIDM00169	Head and Neck Carcinoma	GDSC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.587
p.F48L	SIDM01469	Pancreatic Carcinoma	GDSC	LAPSGTSVPFWVRM	DEG_ODPH_VHL_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14773	Intercellular adhesion molecule 4	DEG_ODPH_VHL_1	39:52	LAPSGTSVPFWVRM	VHL	0.8722	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons