DegronMD

Uniprot ID: Q9NZJ0

Source protein: Denticleless protein homolog

Source gene: DTL

Class: DEG_ODPH_VHL_1

Location: 209:221

E3 ligase: VHL

DEGRON score: 0.6196

ASA_SCORE: 53.5538

COIL: 0.6091

CONS_SCORE: 0.5039

DSS_SCORE: 0.3309

HELIX: 0.0321

FCONS_SCORE: 1.0473

RIG_SCORE: 0.7822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G208V	TCGA-B8-A54J	KIRC	TCGA	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.3056
p.L223I	TCGA-D3-A3C8	SKCM	TCGA	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.2778
p.K202E	TCGA-VQ-A8P2	STAD	TCGA	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.25
p.S219F	DO1128	BRCA	ICGC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.7982
p.R228Q	DO6048	BRCA	ICGC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.1389
p.R211Q	DO50449	ESAD	ICGC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.7329
p.S225N	DO228827	LICA	ICGC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.2222
p.A209S	DO228976	LICA	ICGC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.7588
p.R204L	DO229029	LICA	ICGC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.1944
p.P223S	DO51268	SKCM	ICGC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.2778
p.A216S	DO42472	UCEC	ICGC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.7588
p.K201N	SIDM00837	Colorectal Carcinoma	GDSC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.2222
p.K201N	ACH-000958	Colon/Colorectal Cancer	CCLE	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.2222
p.D226Y	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.1944
p.D226Y	CW-2	large_intestine	COSMIC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.1944
p.S217F	Mewo	skin	COSMIC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.7982
p.L230F	CP66-MEL	skin	COSMIC	LAPSVDFQQSVTV	DEG_ODPH_VHL_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZJ0	Denticleless protein homolog	DEG_ODPH_VHL_1	209:221	LAPSVDFQQSVTV	VHL	0.6196	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons