DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LAPTNLSNLGTMDI
Uniprot ID:
Q2M2H8
Source protein:
Probable maltase-glucoamylase 2
Source gene:
MGAM2
Class:
DEG_ODPH_VHL_1
Location:
2405:2418
E3 ligase:
VHL
DEGRON score:
0.7151
ASA_SCORE:
67.7214
COIL:
0.5502
CONS_SCORE:
0
DSS_SCORE:
0.3929
HELIX:
0.0595
FCONS_SCORE:
0
RIG_SCORE:
0.7424
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MGAM2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPTNLSNLGTMDI
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2M2H8
Probable maltase-glucoamylase 2
DEG_ODPH_VHL_1
2405:2418
LAPTNLSNLGTMDI
VHL
0.7151
More...