DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
LAPVTNSSGKMAL
Uniprot ID:
Q9Y6F6
Source protein:
Inositol 1,4,5-triphosphate receptor associated 1
Source gene:
IRAG1
Class:
DEG_ODPH_VHL_1
Location:
298:310
E3 ligase:
VHL
DEGRON score:
0.9901
ASA_SCORE:
79.3462
COIL:
0.8593
CONS_SCORE:
0.5476
DSS_SCORE:
0.6297
HELIX:
0.0847
FCONS_SCORE:
1.02
RIG_SCORE:
0.6435
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E291K
SIDM00095
Glioblastoma
GDSC
LAPVTNSSGKMAL
DEG_ODPH_VHL_1
0.1389
p.V309I
SIDM00528
Breast Carcinoma
GDSC
LAPVTNSSGKMAL
DEG_ODPH_VHL_1
0.7076
Drug responses associated with IRAG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPVTNSSGKMAL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y6F6
Inositol 1,4,5-triphosphate receptor associated 1
DEG_ODPH_VHL_1
298:310
LAPVTNSSGKMAL
VHL
0.9901
More...