DegronMD

Uniprot ID: Q16665

Source protein: Hypoxia-inducible factor 1-alpha

Source gene: HIF1A

Class: DEG_ODPH_VHL_1

Location: 562:574

E3 ligase: VHL

DEGRON score: 0.9994

ASA_SCORE: 80.7462

COIL: 0.7812

CONS_SCORE: 0.7866

DSS_SCORE: 0.4296

HELIX: 0.1508

FCONS_SCORE: 1.0492

RIG_SCORE: 0.8118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K571N	TCGA-AN-A046	BRCA	TCGA	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.6918
p.K571N	TCGA-BS-A0UV	UCEC	TCGA	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.6918
p.K571N	SIDM01611	Endometrial Carcinoma	GDSC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.6918
p.E584D	TCGA-AN-A046	BRCA	TCGA	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.0556
p.A553S	DO228952	LICA	ICGC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.0833
p.I576F	DO22857	LIHC	ICGC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.7222
p.Q577H	DO46483	OV	ICGC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.25
p.L563R	SIDM01043	Other Sarcomas	GDSC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.8428
p.L563R	ESS-1	endometrium	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.8428
p.V560A	SIDM00537	Colorectal Carcinoma	GDSC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.2778
p.V560A	GP5d	large_intestine	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.2778
p.A581P	NCI-H650	lung	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.1389
p.R572P	KMH-2	thyroid	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.7512
p.R572H	SNU-283	large_intestine	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.8244
p.R572H	NCI-H187	lung	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.8244
p.R572C	KMH-2	thyroid	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.8301
p.M573I	SNU-1040	large_intestine	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.7618
p.D563E	NB17	autonomic_ganglia	COSMIC	LAPYIPMDDDFQL	DEG_ODPH_VHL_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16665	Hypoxia-inducible factor 1-alpha	DEG_ODPH_VHL_1	562:574	LAPYIPMDDDFQL	VHL	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons