DegronMD

Uniprot ID: Q8NBF1

Source protein: Zinc finger protein GLIS1

Source gene: GLIS1

Class: DEG_SCF_FBW7_1

Location: 31:37

E3 ligase: FBXW7

DEGRON score: 0.9914

ASA_SCORE: 50.3

COIL: 0.8816

CONS_SCORE: 0.3985

DSS_SCORE: 0.4131

HELIX: 0.071

FCONS_SCORE: 1.2007

RIG_SCORE: 0.6959

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L26P	TCGA-06-2569	GBM	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.1944
p.L26P	DO12202	GBM	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.1944
p.G28S	TCGA-3N-A9WC	SKCM	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.25
p.G28S	DO51234	SKCM	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.25
p.A35E	TCGA-49-AARE	LUAD	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.659
p.A35E	DO218922	LUAD	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.659
p.G28C	TCGA-86-8281	LUAD	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.25
p.G28C	TCGA-AP-A1DK	UCEC	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.25
p.G28C	DO26318	LUAD	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.25
p.G28C	DO42033	UCEC	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.25
p.P34H	TCGA-AP-A1DK	UCEC	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.7694
p.P34H	DO42033	UCEC	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.7694
p.A35V	TCGA-BR-8680	STAD	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	DO47769	STAD	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	SIDM00612	Glioma	GDSC	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	SIDM00316	Glioblastoma	GDSC	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	SIDM01753	Gastric Carcinoma	GDSC	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	ACH-000239	Gastric Cancer	CCLE	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	ACH-000469	Brain Cancer	CCLE	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	ACH-002257	Brain Cancer	CCLE	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	KINGS-1	central_nervous_system	COSMIC	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.A35V	YH-13	central_nervous_system	COSMIC	LATPAPS	DEG_SCF_FBW7_1	0.5825
p.S30N	TCGA-EE-A2GP	SKCM	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.3056
p.S30N	DO37422	SKCM	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.3056
p.R29Q	TCGA-EO-A3B0	UCEC	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.2778
p.R29Q	DO34696	PACA	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.2778
p.R29Q	DO219773	UCEC	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.2778
p.E44K	TCGA-FW-A3R5	SKCM	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.1389
p.E44K	DO37406	SKCM	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.1389
p.E44K	DO231257	THCA	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.1389
p.L26I	TCGA-G3-AAV7	LIHC	TCGA	LATPAPS	DEG_SCF_FBW7_1	0.1944
p.L26I	DO52300	LIHC	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.1944
p.P27L	DO234210	ESAD	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.2222
p.P36L	DO23408	LINC	ICGC	LATPAPS	DEG_SCF_FBW7_1	0.6471
p.T33N	SIDM00929	Chondrosarcoma	GDSC	LATPAPS	DEG_SCF_FBW7_1	0.7055
p.T33N	ACH-000516	Bone Cancer	CCLE	LATPAPS	DEG_SCF_FBW7_1	0.7055
p.T33N	CAL-78	bone	COSMIC	LATPAPS	DEG_SCF_FBW7_1	0.7055

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LATPAPS

Degron related mutations and impact score

Drug responses associated with GLIS1 mutations

All proteins holding degron of LATPAPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NBF1	Zinc finger protein GLIS1	DEG_SCF_FBW7_1	31:37	LATPAPS	FBXW7	0.9914	More...