DegronMD

Uniprot ID: P98164

Source protein: Low-density lipoprotein receptor-related protein 2

Source gene: LRP2

Class: LIG_APCC_ABBA_1

Location: 4277:4282

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6185

ASA_SCORE: 55.3167

COIL: 0.3635

CONS_SCORE: 0.6653

DSS_SCORE: 0.1296

HELIX: 0.0037

FCONS_SCORE: 1.3994

RIG_SCORE: 0.9293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K4291N	TCGA-CM-5861	COAD	TCGA	LDIFED	LIG_APCC_ABBA_1	0.1944
p.K4291N	TCGA-ER-A19F	SKCM	TCGA	LDIFED	LIG_APCC_ABBA_1	0.1944
p.K4291N	DO7918	COAD	ICGC	LDIFED	LIG_APCC_ABBA_1	0.1944
p.K4291N	DO37679	SKCM	ICGC	LDIFED	LIG_APCC_ABBA_1	0.1944
p.W4286C	TCGA-E6-A1LX	UCEC	TCGA	LDIFED	LIG_APCC_ABBA_1	0.2222
p.W4286C	DO41020	UCEC	ICGC	LDIFED	LIG_APCC_ABBA_1	0.2222
p.L4284S	TCGA-EE-A3JD	SKCM	TCGA	LDIFED	LIG_APCC_ABBA_1	0.2778
p.L4284S	DO50299	SKCM	ICGC	LDIFED	LIG_APCC_ABBA_1	0.2778
p.K4289N	TCGA-ER-A19T	SKCM	TCGA	LDIFED	LIG_APCC_ABBA_1	0.25
p.K4289N	DO51251	SKCM	ICGC	LDIFED	LIG_APCC_ABBA_1	0.25
p.G4292E	TCGA-ER-A42L	SKCM	TCGA	LDIFED	LIG_APCC_ABBA_1	0.0556
p.G4292E	DO223910	SKCM	ICGC	LDIFED	LIG_APCC_ABBA_1	0.0556
p.E4290K	TCGA-FS-A1ZN	SKCM	TCGA	LDIFED	LIG_APCC_ABBA_1	0.1111
p.E4290K	DO38165	SKCM	ICGC	LDIFED	LIG_APCC_ABBA_1	0.1111
p.E4281Q	DO48414	BLCA	ICGC	LDIFED	LIG_APCC_ABBA_1	0.5633
p.Q4283K	DO234425	ESAD	ICGC	LDIFED	LIG_APCC_ABBA_1	0.3056
p.E4270K	SIDM01237	Hepatocellular Carcinoma	GDSC	LDIFED	LIG_APCC_ABBA_1	0.1389
p.E4270K	ACH-000739	Liver Cancer	CCLE	LDIFED	LIG_APCC_ABBA_1	0.1389
p.E4270K	ACH-001021	Liver Cancer	CCLE	LDIFED	LIG_APCC_ABBA_1	0.1389
p.E4270K	C3A	liver	COSMIC	LDIFED	LIG_APCC_ABBA_1	0.1389
p.K4291R	SIDM01045	Endometrial Carcinoma	GDSC	LDIFED	LIG_APCC_ABBA_1	0.1944
p.K4291R	ACH-000978	Endometrial/Uterine Cancer	CCLE	LDIFED	LIG_APCC_ABBA_1	0.1944
p.K4291R	EN	endometrium	COSMIC	LDIFED	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98164	Low-density lipoprotein receptor-related protein 2	LIG_APCC_ABBA_1	4277:4282	LDIFED	APC,CDC20,FZR1	0.6185	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons