DegronMD

Uniprot ID: Q6ZS86

Source protein: Putative glycerol kinase 5

Source gene: GK5

Class: LIG_APCC_ABBA_1

Location: 349:354

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6558

ASA_SCORE: 57.6667

COIL: 0.9838

CONS_SCORE: 0.623

DSS_SCORE: 0.2645

HELIX: 0.0092

FCONS_SCORE: 1.0528

RIG_SCORE: 0.8934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K360Q	TCGA-B5-A0JY	UCEC	TCGA	LDLFTD	LIG_APCC_ABBA_1	0.6111
p.K360Q	DO43041	UCEC	ICGC	LDLFTD	LIG_APCC_ABBA_1	0.6111
p.A362S	TCGA-G9-6361	PRAD	TCGA	LDLFTD	LIG_APCC_ABBA_1	0.1111
p.A362S	DO36328	PRAD	ICGC	LDLFTD	LIG_APCC_ABBA_1	0.1111
p.T353K	DO229037	LICA	ICGC	LDLFTD	LIG_APCC_ABBA_1	0.6195
p.D350N	DO23440	LINC	ICGC	LDLFTD	LIG_APCC_ABBA_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZS86	Putative glycerol kinase 5	LIG_APCC_ABBA_1	349:354	LDLFTD	APC,CDC20,FZR1	0.6558	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons