DegronMD

Uniprot ID: Q5T6F2

Source protein: Ubiquitin-associated protein 2

Source gene: UBAP2

Class: DEG_SCF_FBW7_1

Location: 655:661

E3 ligase: FBXW7

DEGRON score: 0.9727

ASA_SCORE: 103.7429

COIL: 0.9683

CONS_SCORE: 0.4042

DSS_SCORE: 0.8075

HELIX: 0.0103

FCONS_SCORE: 0.9253

RIG_SCORE: 0.636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S665F	TCGA-77-A5G3	LUSC	TCGA	LDTPKTT	DEG_SCF_FBW7_1	0.6667
p.S665F	DO45456	LUSC	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.6667
p.R650Q	TCGA-A5-A2K5	UCEC	TCGA	LDTPKTT	DEG_SCF_FBW7_1	0.1944
p.R650Q	TCGA-EI-6917	READ	TCGA	LDTPKTT	DEG_SCF_FBW7_1	0.1944
p.R650Q	DO36881	READ	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.1944
p.R650Q	DO41379	UCEC	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.1944
p.K659N	TCGA-AA-A00N	COAD	TCGA	LDTPKTT	DEG_SCF_FBW7_1	0.5806
p.K659N	TCGA-EO-A22R	UCEC	TCGA	LDTPKTT	DEG_SCF_FBW7_1	0.5806
p.K659N	DO9876	COAD	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.5806
p.K659N	DO42713	UCEC	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.5806
p.Q653H	TCGA-E5-A4U1	BLCA	TCGA	LDTPKTT	DEG_SCF_FBW7_1	0.2778
p.Q653H	DO44061	BLCA	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.2778
p.Q653K	DO228929	LICA	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.2778
p.P671H	DO229019	LICA	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.0556
p.P667Q	DO229028	LICA	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.1667
p.A666D	DO229045	LICA	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.1944
p.R670Q	DO43306	UCEC	ICGC	LDTPKTT	DEG_SCF_FBW7_1	0.0833
p.G662S	SIDM00565	Oral Cavity Carcinoma	GDSC	LDTPKTT	DEG_SCF_FBW7_1	0.3056
p.G662S	ACH-001626	Head and Neck Cancer	CCLE	LDTPKTT	DEG_SCF_FBW7_1	0.3056
p.G662S	OSC-20	upper_aerodigestive_tract	COSMIC	LDTPKTT	DEG_SCF_FBW7_1	0.3056
p.L667I	SIDM01117	Small Cell Lung Carcinoma	GDSC	LDTPKTT	DEG_SCF_FBW7_1	0.1667
p.L667I	SIDM00954	Breast Carcinoma	GDSC	LDTPKTT	DEG_SCF_FBW7_1	0.1667
p.L667I	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LDTPKTT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T6F2	Ubiquitin-associated protein 2	DEG_SCF_FBW7_1	655:661	LDTPKTT	FBXW7	0.9727	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons