DegronMD

Uniprot ID: P14222

Source protein: Perforin-1

Source gene: PRF1

Class: DEG_SCF_FBW7_1

Location: 133:140

E3 ligase: FBXW7

DEGRON score: 0.8917

ASA_SCORE: 59.4125

COIL: 0.5229

CONS_SCORE: 0.5142

DSS_SCORE: 0.4268

HELIX: 0.0246

FCONS_SCORE: 0.7936

RIG_SCORE: 0.7179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G132R	TCGA-AJ-A23O	UCEC	TCGA	LDVTPKPT	DEG_SCF_FBW7_1	0.3056
p.G132R	DO43290	UCEC	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.3056
p.R123H	TCGA-AJ-A3EL	UCEC	TCGA	LDVTPKPT	DEG_SCF_FBW7_1	0.0556
p.R123H	TCGA-EO-A22U	UCEC	TCGA	LDVTPKPT	DEG_SCF_FBW7_1	0.0556
p.R123H	DO41542	UCEC	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.0556
p.R123H	DO43755	UCEC	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.0556
p.R123H	SIDM00684	Glioblastoma	GDSC	LDVTPKPT	DEG_SCF_FBW7_1	0.0556
p.S124I	TCGA-B5-A1MX	UCEC	TCGA	LDVTPKPT	DEG_SCF_FBW7_1	0.0833
p.S124I	DO41999	UCEC	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.0833
p.D128N	TCGA-D3-A3C8	SKCM	TCGA	LDVTPKPT	DEG_SCF_FBW7_1	0.1944
p.D128N	DO47636	SKCM	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.1944
p.G132W	TCGA-D3-A3CB	SKCM	TCGA	LDVTPKPT	DEG_SCF_FBW7_1	0.3056
p.G132W	TCGA-EE-A2GI	SKCM	TCGA	LDVTPKPT	DEG_SCF_FBW7_1	0.3056
p.G132W	DO37410	SKCM	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.3056
p.G132W	DO47386	SKCM	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.3056
p.G132W	ACH-000901	Lung Cancer	CCLE	LDVTPKPT	DEG_SCF_FBW7_1	0.3056
p.R126C	TCGA-FP-A4BE	STAD	TCGA	LDVTPKPT	DEG_SCF_FBW7_1	0.1389
p.R126C	DO48016	STAD	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.1389
p.A148D	DO229037	LICA	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.1111
p.P139T	DO229045	LICA	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.5919
p.P139T	ACH-002396	Bone Cancer	CCLE	LDVTPKPT	DEG_SCF_FBW7_1	0.5919
p.P139T	Sarc9371	bone	COSMIC	LDVTPKPT	DEG_SCF_FBW7_1	0.5919
p.R126H	DO229250	THCA	ICGC	LDVTPKPT	DEG_SCF_FBW7_1	0.1389
p.R126S	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LDVTPKPT	DEG_SCF_FBW7_1	0.1389
p.R126S	ACH-000855	Esophageal Cancer	CCLE	LDVTPKPT	DEG_SCF_FBW7_1	0.1389
p.R126S	KYSE-150	oesophagus	COSMIC	LDVTPKPT	DEG_SCF_FBW7_1	0.1389
p.P139L	ACH-002396	Bone Cancer	CCLE	LDVTPKPT	DEG_SCF_FBW7_1	0.6471
p.P139L	Sarc9371	bone	COSMIC	LDVTPKPT	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14222	Perforin-1	DEG_SCF_FBW7_1	133:140	LDVTPKPT	FBXW7	0.8917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDVTPKPT

Degron related mutations and impact score

Drug responses associated with PRF1 mutations

All proteins holding degron of LDVTPKPT