DegronMD

Uniprot ID: Q4ZHG4

Source protein: Fibronectin type III domain-containing protein 1

Source gene: FNDC1

Class: DEG_SCF_FBW7_1

Location: 1395:1402

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 76.7

COIL: 0.8974

CONS_SCORE: 0.7847

DSS_SCORE: 0.4575

HELIX: 0.0189

FCONS_SCORE: 0.9696

RIG_SCORE: 0.7397

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1405D	TCGA-BS-A0UF	UCEC	TCGA	LEGTPVVS	DEG_SCF_FBW7_1	0.25
p.P1399T	TCGA-CN-5360	HNSC	TCGA	LEGTPVVS	DEG_SCF_FBW7_1	0.7031
p.P1399T	TCGA-CV-7089	HNSC	TCGA	LEGTPVVS	DEG_SCF_FBW7_1	0.7031
p.G1387V	TCGA-ER-A19P	SKCM	TCGA	LEGTPVVS	DEG_SCF_FBW7_1	0.1111
p.P1399L	TCGA-FW-A3R5	SKCM	TCGA	LEGTPVVS	DEG_SCF_FBW7_1	0.7582
p.T1406I	DO3880	BRCA	ICGC	LEGTPVVS	DEG_SCF_FBW7_1	0.2222
p.T1395M	DO222427	BTCA	ICGC	LEGTPVVS	DEG_SCF_FBW7_1	0.7423
p.P1403L	DO51595	CESC	ICGC	LEGTPVVS	DEG_SCF_FBW7_1	0.3056
p.M1388I	DO229177	LMS	ICGC	LEGTPVVS	DEG_SCF_FBW7_1	0.1389
p.T1391N	DO51954	PRAD	ICGC	LEGTPVVS	DEG_SCF_FBW7_1	0.6667
p.D1404N	SIDM00928	Breast Carcinoma	GDSC	LEGTPVVS	DEG_SCF_FBW7_1	0.2778
p.D1404N	ACH-000857	Breast Cancer	CCLE	LEGTPVVS	DEG_SCF_FBW7_1	0.2778
p.D1404N	ACH-001536	Bile Duct Cancer	CCLE	LEGTPVVS	DEG_SCF_FBW7_1	0.2778
p.D1404N	CAL-85-1	breast	COSMIC	LEGTPVVS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SCF_FBW7_1	1395:1402	LEGTPVVS	FBXW7	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons