DegronMD

Uniprot ID: A8MT33

Source protein: Synaptonemal complex central element protein 1-like

Source gene: SYCE1L

Class: LIG_APCC_ABBA_1

Location: 199:204

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5332

ASA_SCORE: 76.8

COIL: 0.1847

CONS_SCORE: 0.471

DSS_SCORE: 0.4702

HELIX: 0.8042

FCONS_SCORE: 1.0026

RIG_SCORE: 0.7886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G194E	TCGA-CK-4951	COAD	TCGA	LEIFGE	LIG_APCC_ABBA_1	0.1944
p.G194E	DO10582	COAD	ICGC	LEIFGE	LIG_APCC_ABBA_1	0.1944
p.G194E	DO47911	STAD	ICGC	LEIFGE	LIG_APCC_ABBA_1	0.1944
p.P210T	DO229005	COCA	ICGC	LEIFGE	LIG_APCC_ABBA_1	0.1667
p.P210T	DO231102	LUSC	ICGC	LEIFGE	LIG_APCC_ABBA_1	0.1667
p.P210T	DO231149	LUSC	ICGC	LEIFGE	LIG_APCC_ABBA_1	0.1667
p.R207L	DO229022	LICA	ICGC	LEIFGE	LIG_APCC_ABBA_1	0.25
p.A209S	DO229032	LICA	ICGC	LEIFGE	LIG_APCC_ABBA_1	0.1944
p.A214S	DO229006	LICA	ICGC	LEIFGE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MT33	Synaptonemal complex central element protein 1-like	LIG_APCC_ABBA_1	199:204	LEIFGE	APC,CDC20,FZR1	0.5332	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons