DegronMD

Uniprot ID: Q9Y3Z3

Source protein: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Source gene: SAMHD1

Class: LIG_APCC_ABBA_1

Location: 36:41

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9985

ASA_SCORE: 75.5667

COIL: 0.8437

CONS_SCORE: 0.2453

DSS_SCORE: 0.4846

HELIX: 0.0777

FCONS_SCORE: 0.9138

RIG_SCORE: 0.7108

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E37A	TCGA-19-5956	GBM	TCGA	LELHPD	LIG_APCC_ABBA_1	0.659
p.E37A	DO13863	GBM	ICGC	LELHPD	LIG_APCC_ABBA_1	0.659
p.H39Y	TCGA-D3-A3MR	SKCM	TCGA	LELHPD	LIG_APCC_ABBA_1	0.6118
p.H39Y	DO47256	SKCM	ICGC	LELHPD	LIG_APCC_ABBA_1	0.6118
p.E48V	TCGA-EO-A22R	UCEC	TCGA	LELHPD	LIG_APCC_ABBA_1	0.1389
p.E48V	DO42713	UCEC	ICGC	LELHPD	LIG_APCC_ABBA_1	0.1389
p.G46S	TCGA-FT-A3EE	BLCA	TCGA	LELHPD	LIG_APCC_ABBA_1	0.1944
p.G46S	DO720	BLCA	ICGC	LELHPD	LIG_APCC_ABBA_1	0.1944
p.D31E	DO229026	LICA	ICGC	LELHPD	LIG_APCC_ABBA_1	0.1944
p.C51F	ACH-000901	Lung Cancer	CCLE	LELHPD	LIG_APCC_ABBA_1	0.0556
p.S33F	ACH-001379	Pancreatic Cancer	CCLE	LELHPD	LIG_APCC_ABBA_1	0.6944
p.P40L	ACH-001970	Metastasis	CCLE	LELHPD	LIG_APCC_ABBA_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Z3	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	LIG_APCC_ABBA_1	36:41	LELHPD	APC,CDC20,FZR1	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons