DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
LELHTE
Uniprot ID:
P17040
Source protein:
Zinc finger and SCAN domain-containing protein 20
Source gene:
ZSCAN20
Class:
LIG_APCC_ABBA_1
Location:
141:146
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8881
ASA_SCORE:
96.0333
COIL:
0.6875
CONS_SCORE:
0.5748
DSS_SCORE:
0.6757
HELIX:
0.2002
FCONS_SCORE:
1.0902
RIG_SCORE:
0.6968
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P150S
TCGA-AA-3968
COAD
TCGA
LELHTE
LIG_APCC_ABBA_1
0.2222
p.P150S
DO9178
COAD
ICGC
LELHTE
LIG_APCC_ABBA_1
0.2222
Drug responses associated with ZSCAN20 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LELHTE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P17040
Zinc finger and SCAN domain-containing protein 20
LIG_APCC_ABBA_1
141:146
LELHTE
APC,CDC20,FZR1
0.8881
More...