DegronMD

Uniprot ID: P24928

Source protein: DNA-directed RNA polymerase II subunit RPB1

Source gene: POLR2A

Class: DEG_SCF_FBW7_1

Location: 725:732

E3 ligase: FBXW7

DEGRON score: 0.7123

ASA_SCORE: 66.8875

COIL: 0.9666

CONS_SCORE: 0.389

DSS_SCORE: 0.6159

HELIX: 0.0188

FCONS_SCORE: 0.9965

RIG_SCORE: 0.6794

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G730W	TCGA-CC-5262	LIHC	TCGA	LEPTPGNT	DEG_SCF_FBW7_1	0.6714
p.G730W	DO22953	LIHC	ICGC	LEPTPGNT	DEG_SCF_FBW7_1	0.6714
p.E724K	TCGA-XF-A9SY	BLCA	TCGA	LEPTPGNT	DEG_SCF_FBW7_1	0.3056
p.E724K	DO51918	BLCA	ICGC	LEPTPGNT	DEG_SCF_FBW7_1	0.3056
p.R734W	DO233272	GACA	ICGC	LEPTPGNT	DEG_SCF_FBW7_1	0.2778
p.T736M	DO233444	PRAD	ICGC	LEPTPGNT	DEG_SCF_FBW7_1	0.6667
p.F737C	DO36556	READ	ICGC	LEPTPGNT	DEG_SCF_FBW7_1	0.1944
p.E738D	SIDM00509	Small Cell Lung Carcinoma	GDSC	LEPTPGNT	DEG_SCF_FBW7_1	0.1667
p.E738D	ACH-000187	Lung Cancer	CCLE	LEPTPGNT	DEG_SCF_FBW7_1	0.1667
p.I717F	SIDM00392	Melanoma	GDSC	LEPTPGNT	DEG_SCF_FBW7_1	0.1111
p.I717F	ACH-000810	Skin Cancer	CCLE	LEPTPGNT	DEG_SCF_FBW7_1	0.1111
p.A720V	SIDM00781	Colorectal Carcinoma	GDSC	LEPTPGNT	DEG_SCF_FBW7_1	0.1944
p.A720V	SIDM00780	Colorectal Carcinoma	GDSC	LEPTPGNT	DEG_SCF_FBW7_1	0.1944
p.A720V	ACH-000967	Colon/Colorectal Cancer	CCLE	LEPTPGNT	DEG_SCF_FBW7_1	0.1944
p.A720V	ACH-001199	Colon/Colorectal Cancer	CCLE	LEPTPGNT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24928	DNA-directed RNA polymerase II subunit RPB1	DEG_SCF_FBW7_1	725:732	LEPTPGNT	FBXW7	0.7123	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons