DegronMD

Uniprot ID: P05067

Source protein: Amyloid-beta precursor protein

Source gene: APP

Class: DEG_SCF_FBW7_2

Location: 379:385

E3 ligase: FBXW7

DEGRON score: 0.9544

ASA_SCORE: 44.3571

COIL: 0.7417

CONS_SCORE: 0.3644

DSS_SCORE: 0.625

HELIX: 0.1174

FCONS_SCORE: 0.8683

RIG_SCORE: 0.6378

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K393E	TCGA-05-4398	LUAD	TCGA	LETPGDE	DEG_SCF_FBW7_2	0.5556
p.E380K	TCGA-CN-A6V7	HNSC	TCGA	LETPGDE	DEG_SCF_FBW7_2	0.591
p.E380K	SIDM01716	Non-Cancerous	GDSC	LETPGDE	DEG_SCF_FBW7_2	0.591
p.E380K	SIDM00175	Melanoma	GDSC	LETPGDE	DEG_SCF_FBW7_2	0.591
p.E380K	ACH-002096	Skin Cancer	CCLE	LETPGDE	DEG_SCF_FBW7_2	0.591
p.E380K	ACH-002346	Non-Cancerous	CCLE	LETPGDE	DEG_SCF_FBW7_2	0.591
p.A394T	TCGA-DF-A2KU	UCEC	TCGA	LETPGDE	DEG_SCF_FBW7_2	0.0833
p.G383W	TCGA-EE-A2MM	SKCM	TCGA	LETPGDE	DEG_SCF_FBW7_2	0.6714
p.F391V	TCGA-Z2-A8RT	SKCM	TCGA	LETPGDE	DEG_SCF_FBW7_2	0.1667
p.E385Q	DO225168	BRCA	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.6744
p.E382K	DO230311	COCA	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.7022
p.E382K	DO23258	LINC	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.7022
p.Q394R	DO230335	COCA	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.0833
p.D373E	DO229031	LICA	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.1667
p.K374E	DO25847	LUAD	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.1944
p.A393S	DO26150	LUAD	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.5556
p.R385C	DO232675	PBCA	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.8301
p.R385C	DO41871	UCEC	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.8301
p.R385C	SK-UT-1	soft_tissue	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.8301
p.F372V	DO51301	SKCM	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.1389
p.F381L	DO41133	UCEC	ICGC	LETPGDE	DEG_SCF_FBW7_2	0.6981
p.K395N	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	LETPGDE	DEG_SCF_FBW7_2	0.1667
p.K395N	ACH-000665	Lung Cancer	CCLE	LETPGDE	DEG_SCF_FBW7_2	0.1667
p.K395N	SK-MES-1	lung	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.1667
p.A369V	SIDM00789	Colorectal Carcinoma	GDSC	LETPGDE	DEG_SCF_FBW7_2	0.0556
p.A369V	ACH-000997	Colon/Colorectal Cancer	CCLE	LETPGDE	DEG_SCF_FBW7_2	0.0556
p.A369V	ACH-001061	Colon/Colorectal Cancer	CCLE	LETPGDE	DEG_SCF_FBW7_2	0.0556
p.A369V	HCT-15	large_intestine	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.0556
p.H388Y	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LETPGDE	DEG_SCF_FBW7_2	0.25
p.H388Y	ACH-000937	Leukemia	CCLE	LETPGDE	DEG_SCF_FBW7_2	0.25
p.H388Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.25
p.E385K	ACH-001415	Bladder Cancer	CCLE	LETPGDE	DEG_SCF_FBW7_2	0.7022
p.M382V	EN	endometrium	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.7208
p.A393T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.5556
p.K379N	TE-9	oesophagus	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.6918
p.K379N	JHH-4	liver	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.6918
p.K379N	KYM-1	soft_tissue	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.6918
p.Q384H	CW-2	large_intestine	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.7582
p.R395C	SNU-1040	large_intestine	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.1667
p.Q389H	CW-2	large_intestine	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.2222
p.E393K	EPLC-272H	lung	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.5556
p.H380Y	HSC-39	stomach	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.7229
p.M387V	EN	endometrium	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.2778
p.H369Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.0556
p.A369S	CAL-12T	lung	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.0556
p.K371N	SK-MES-1	lung	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.1111
p.D371H	NCI-H510A	lung	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.1111
p.P389H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.2222
p.K376N	SK-MES-1	lung	COSMIC	LETPGDE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LETPGDE

Degron related mutations and impact score

Drug responses associated with APP mutations

All proteins holding degron of LETPGDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05067	Amyloid-beta precursor protein	DEG_SCF_FBW7_2	379:385	LETPGDE	FBXW7	0.9544	More...