DegronMD

Uniprot ID: P31689

Source protein: DnaJ homolog subfamily A member 1

Source gene: DNAJA1

Class: LIG_APCC_ABBA_1

Location: 208:213

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7863

ASA_SCORE: 48.7167

COIL: 0.2295

CONS_SCORE: 0.6241

DSS_SCORE: 0.4552

HELIX: 0.0008

FCONS_SCORE: 1.1569

RIG_SCORE: 0.834

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D210N	DO44362	CESC	ICGC	LEVHID	LIG_APCC_ABBA_1	0.6932
p.L208I	TCGA-L9-A444	LUAD	TCGA	LEVHID	LIG_APCC_ABBA_1	0.6063
p.K217R	TCGA-G4-6588	COAD	TCGA	LEVHID	LIG_APCC_ABBA_1	0.3333
p.M216I	TCGA-E2-A108	BRCA	TCGA	LEVHID	LIG_APCC_ABBA_1	0.25
p.M216I	DO5731	BRCA	ICGC	LEVHID	LIG_APCC_ABBA_1	0.25
p.G221V	DO37591	SKCM	ICGC	LEVHID	LIG_APCC_ABBA_1	0.2222
p.R203P	ACH-000975	Lung Cancer	CCLE	LEVHID	LIG_APCC_ABBA_1	0.1944

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31689	DnaJ homolog subfamily A member 1	LIG_APCC_ABBA_1	208:213	LEVHID	APC,CDC20,FZR1	0.7863	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons