DegronMD

Uniprot ID: Q9NR09

Source protein: Baculoviral IAP repeat-containing protein 6

Source gene: BIRC6

Class: DEG_SCF_FBW7_1

Location: 1703:1710

E3 ligase: FBXW7

DEGRON score: 0.9942

ASA_SCORE: 72.025

COIL: 0.8765

CONS_SCORE: 0.5174

DSS_SCORE: 0.4648

HELIX: 0.0509

FCONS_SCORE: 1.1555

RIG_SCORE: 0.736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1719A	TCGA-AA-3864	COAD	TCGA	LFMTPPLT	DEG_SCF_FBW7_1	0.0833
p.V1719A	DO8490	COAD	ICGC	LFMTPPLT	DEG_SCF_FBW7_1	0.0833
p.V1716I	TCGA-AA-3984	COAD	TCGA	LFMTPPLT	DEG_SCF_FBW7_1	0.1667
p.V1716I	DO9002	COAD	ICGC	LFMTPPLT	DEG_SCF_FBW7_1	0.1667
p.A1715S	TCGA-BP-5169	KIRC	TCGA	LFMTPPLT	DEG_SCF_FBW7_1	0.1944
p.A1715S	DO18075	KIRC	ICGC	LFMTPPLT	DEG_SCF_FBW7_1	0.1944
p.T1710S	TCGA-XR-A8TG	LIHC	TCGA	LFMTPPLT	DEG_SCF_FBW7_1	0.7116
p.T1710S	DO223924	LIHC	ICGC	LFMTPPLT	DEG_SCF_FBW7_1	0.7116
p.L1703F	TCGA-ZF-A9RC	BLCA	TCGA	LFMTPPLT	DEG_SCF_FBW7_1	0.6981
p.L1703F	DO219068	BLCA	ICGC	LFMTPPLT	DEG_SCF_FBW7_1	0.6981
p.V1693A	DO222798	COCA	ICGC	LFMTPPLT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR09	Baculoviral IAP repeat-containing protein 6	DEG_SCF_FBW7_1	1703:1710	LFMTPPLT	FBXW7	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons