DegronMD

Uniprot ID: Q9H898

Source protein: Zinc finger matrin-type protein 4

Source gene: ZMAT4

Class: DEG_SCF_SKP2-CKS1_1

Location: 107:114

E3 ligase: SKP2,CSK1

DEGRON score: 0.9843

ASA_SCORE: 106.6875

COIL: 0.8918

CONS_SCORE: 0.7365

DSS_SCORE: 0.4098

HELIX: 0.0923

FCONS_SCORE: 0.9646

RIG_SCORE: 0.7394

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P112S	TCGA-A5-A0G2	UCEC	TCGA	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P112S	DO41235	UCEC	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.6752
p.H99Y	TCGA-BF-A1Q0	SKCM	TCGA	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.H99Y	DO47374	SKCM	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.K124R	TCGA-BR-A4PD	STAD	TCGA	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.K124R	DO47831	STAD	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.T115I	TCGA-BS-A0UF	UCEC	TCGA	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.75
p.T115I	TCGA-DU-6392	LGG	TCGA	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.75
p.T115I	TCGA-ER-A194	SKCM	TCGA	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.75
p.T115I	DO22237	LGG	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.75
p.T115I	DO47646	SKCM	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.75
p.T115I	DO41488	UCEC	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.75
p.R120H	DO9876	COAD	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.L123R	DO50452	ESAD	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L123P	DO234245	ESAD	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.0833
p.K124T	DO234450	ESAD	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.T111N	DO229018	LICA	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.8166
p.R120S	DO229038	LICA	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R120S	DO26468	LUSC	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.1667
p.G108R	DO50970	LICA	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.6457
p.P112Q	DO232224	PBCA	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.7035
p.K104I	DO229456	SKCA	ICGC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.3611
p.L106M	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	LGEKTPLK	DEG_SCF_SKP2-CKS1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H898	Zinc finger matrin-type protein 4	DEG_SCF_SKP2-CKS1_1	107:114	LGEKTPLK	SKP2,CSK1	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons