DegronMD

Uniprot ID: Q6P9G9

Source protein: Zinc finger protein 449

Source gene: ZNF449

Class: DEG_SCF_FBW7_1

Location: 295:302

E3 ligase: FBXW7

DEGRON score: 0.9212

ASA_SCORE: 72.875

COIL: 0.8336

CONS_SCORE: 0.5241

DSS_SCORE: 0.7754

HELIX: 0.0749

FCONS_SCORE: 0.9701

RIG_SCORE: 0.5967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S302C	TCGA-06-6694	GBM	TCGA	LGETPENS	DEG_SCF_FBW7_1	0.7541
p.S302C	DO11052	GBM	ICGC	LGETPENS	DEG_SCF_FBW7_1	0.7541
p.G296A	TCGA-17-Z050	LUAD	TCGA	LGETPENS	DEG_SCF_FBW7_1	0.6429
p.E306K	TCGA-AO-A03U	BRCA	TCGA	LGETPENS	DEG_SCF_FBW7_1	0.2222
p.E306K	DO2978	BRCA	ICGC	LGETPENS	DEG_SCF_FBW7_1	0.2222
p.E305K	TCGA-EO-A22R	UCEC	TCGA	LGETPENS	DEG_SCF_FBW7_1	0.25
p.E305K	DO42713	UCEC	ICGC	LGETPENS	DEG_SCF_FBW7_1	0.25
p.L308F	TCGA-EQ-8122	STAD	TCGA	LGETPENS	DEG_SCF_FBW7_1	0.1667
p.L308F	DO38867	STAD	ICGC	LGETPENS	DEG_SCF_FBW7_1	0.1667
p.P293L	DO233205	GACA	ICGC	LGETPENS	DEG_SCF_FBW7_1	0.2778
p.Q291H	DO232009	ORCA	ICGC	LGETPENS	DEG_SCF_FBW7_1	0.2222
p.E300G	SIDM00185	Melanoma	GDSC	LGETPENS	DEG_SCF_FBW7_1	0.6087
p.E300G	SIDM01650	Non-Cancerous	GDSC	LGETPENS	DEG_SCF_FBW7_1	0.6087
p.E300G	ACH-002354	Non-Cancerous	CCLE	LGETPENS	DEG_SCF_FBW7_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P9G9	Zinc finger protein 449	DEG_SCF_FBW7_1	295:302	LGETPENS	FBXW7	0.9212	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons