DegronMD

Uniprot ID: Q15233

Source protein: Non-POU domain-containing octamer-binding protein

Source gene: NONO

Class: DEG_SCF_FBW7_1

Location: 425:432

E3 ligase: FBXW7

DEGRON score: 0.9519

ASA_SCORE: 72.525

COIL: 0.8856

CONS_SCORE: 0.3569

DSS_SCORE: 0.7131

HELIX: 0.0761

FCONS_SCORE: 0.9137

RIG_SCORE: 0.6955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T431P	TCGA-AX-A2HD	UCEC	TCGA	LGLTPPTT	DEG_SCF_FBW7_1	0.7031
p.T431P	DO42608	UCEC	ICGC	LGLTPPTT	DEG_SCF_FBW7_1	0.7031
p.G423R	TCGA-GN-A262	SKCM	TCGA	LGLTPPTT	DEG_SCF_FBW7_1	0.2778
p.G423R	DO37515	SKCM	ICGC	LGLTPPTT	DEG_SCF_FBW7_1	0.2778
p.P429T	TCGA-MX-A5UJ	STAD	TCGA	LGLTPPTT	DEG_SCF_FBW7_1	0.7031
p.P429T	DO48547	STAD	ICGC	LGLTPPTT	DEG_SCF_FBW7_1	0.7031
p.M420I	DO229025	LICA	ICGC	LGLTPPTT	DEG_SCF_FBW7_1	0.1944
p.A439S	DO229036	LICA	ICGC	LGLTPPTT	DEG_SCF_FBW7_1	0.1389
p.D422Y	SIDM00841	Colorectal Carcinoma	GDSC	LGLTPPTT	DEG_SCF_FBW7_1	0.25
p.D422Y	ACH-000651	Colon/Colorectal Cancer	CCLE	LGLTPPTT	DEG_SCF_FBW7_1	0.25
p.D422Y	SW620	large_intestine	COSMIC	LGLTPPTT	DEG_SCF_FBW7_1	0.25
p.D422G	SIDM00217	Colorectal Carcinoma	GDSC	LGLTPPTT	DEG_SCF_FBW7_1	0.25
p.D422G	ACH-000999	Colon/Colorectal Cancer	CCLE	LGLTPPTT	DEG_SCF_FBW7_1	0.25
p.D422G	SNU-1040	large_intestine	COSMIC	LGLTPPTT	DEG_SCF_FBW7_1	0.25
p.M420K	ACH-001853	Bile Duct Cancer	CCLE	LGLTPPTT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15233	Non-POU domain-containing octamer-binding protein	DEG_SCF_FBW7_1	425:432	LGLTPPTT	FBXW7	0.9519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons