DegronMD

Uniprot ID: Q92570

Source protein: Nuclear receptor subfamily 4 group A member 3

Source gene: NR4A3

Class: DEG_SCF_FBW7_1

Location: 259:266

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 79.0375

COIL: 0.9421

CONS_SCORE: 0.4047

DSS_SCORE: 0.4703

HELIX: 0.0303

FCONS_SCORE: 0.9777

RIG_SCORE: 0.6299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T262A	DO227802	COCA	ICGC	LGLTPSPT	DEG_SCF_FBW7_1	0.7139
p.A251V	DO233903	GACA	ICGC	LGLTPSPT	DEG_SCF_FBW7_1	0.1111
p.P275S	DO37432	SKCM	ICGC	LGLTPSPT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92570	Nuclear receptor subfamily 4 group A member 3	DEG_SCF_FBW7_1	259:266	LGLTPSPT	FBXW7	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons