DegronMD

Uniprot ID: Q9BQC3

Source protein: 2-

Source gene: DPH2

Class: DEG_SCF_FBW7_2

Location: 464:471

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 72.9125

COIL: 0.7423

CONS_SCORE: 0.4089

DSS_SCORE: 0.5062

HELIX: 0.0631

FCONS_SCORE: 0.7318

RIG_SCORE: 0.7258

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E471K	TCGA-19-5956	GBM	TCGA	LGQTPVTE	DEG_SCF_FBW7_2	0.7022
p.G465C	TCGA-BR-4362	STAD	TCGA	LGQTPVTE	DEG_SCF_FBW7_2	0.6489
p.R477Q	TCGA-2W-A8YY	CESC	TCGA	LGQTPVTE	DEG_SCF_FBW7_2	0.1667
p.R477Q	TCGA-VQ-A8PO	STAD	TCGA	LGQTPVTE	DEG_SCF_FBW7_2	0.1667
p.R477Q	SIDM00861	Ovarian Carcinoma	GDSC	LGQTPVTE	DEG_SCF_FBW7_2	0.1667
p.R477Q	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	LGQTPVTE	DEG_SCF_FBW7_2	0.1667

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQC3	2-	DEG_SCF_FBW7_2	464:471	LGQTPVTE	FBXW7	0.9988	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons