DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LGTPKGS
Uniprot ID:
A2RU54
Source protein:
Homeobox protein HMX2
Source gene:
HMX2
Class:
DEG_SCF_FBW7_1
Location:
89:95
E3 ligase:
FBXW7
DEGRON score:
0.9971
ASA_SCORE:
80.2429
COIL:
0.9357
CONS_SCORE:
0.4348
DSS_SCORE:
0.6265
HELIX:
0.023
FCONS_SCORE:
1.2239
RIG_SCORE:
0.5542
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P92R
ACH-001540
Liposarcoma
CCLE
LGTPKGS
DEG_SCF_FBW7_1
0.7512
p.S95N
SIDM00660
Colorectal Carcinoma
GDSC
LGTPKGS
DEG_SCF_FBW7_1
0.7069
p.S95N
ACH-000985
Colon/Colorectal Cancer
CCLE
LGTPKGS
DEG_SCF_FBW7_1
0.7069
p.S95N
LS-411N
large_intestine
COSMIC
LGTPKGS
DEG_SCF_FBW7_1
0.7069
p.P92S
ACH-001687
Kidney Cancer
CCLE
LGTPKGS
DEG_SCF_FBW7_1
0.6752
p.K93E
TCGA-IB-7651
PAAD
TCGA
LGTPKGS
DEG_SCF_FBW7_1
0.591
p.K93E
DO46657
PAAD
ICGC
LGTPKGS
DEG_SCF_FBW7_1
0.591
p.G96R
TCGA-91-A4BC
LUAD
TCGA
LGTPKGS
DEG_SCF_FBW7_1
0.3056
p.G96R
DO45422
LUAD
ICGC
LGTPKGS
DEG_SCF_FBW7_1
0.3056
p.P87S
TCGA-FR-A3YO
SKCM
TCGA
LGTPKGS
DEG_SCF_FBW7_1
0.2778
p.P87S
DO37419
SKCM
ICGC
LGTPKGS
DEG_SCF_FBW7_1
0.2778
p.P87H
TCGA-GN-A26A
SKCM
TCGA
LGTPKGS
DEG_SCF_FBW7_1
0.2778
p.P87H
DO37861
SKCM
ICGC
LGTPKGS
DEG_SCF_FBW7_1
0.2778
p.G97R
TCGA-RU-A8FL
COAD
TCGA
LGTPKGS
DEG_SCF_FBW7_1
0.2778
p.G97R
DO51733
COAD
ICGC
LGTPKGS
DEG_SCF_FBW7_1
0.2778
p.F86L
TCGA-61-2012
OV
TCGA
LGTPKGS
DEG_SCF_FBW7_1
0.25
p.F86L
DO32536
OV
ICGC
LGTPKGS
DEG_SCF_FBW7_1
0.25
p.E104K
SIDM00879
Breast Carcinoma
GDSC
LGTPKGS
DEG_SCF_FBW7_1
0.0833
p.E104K
SIDM00930
Osteosarcoma
GDSC
LGTPKGS
DEG_SCF_FBW7_1
0.0833
p.R105C
SIDM01180
Hepatocellular Carcinoma
GDSC
LGTPKGS
DEG_SCF_FBW7_1
0.0556
p.R105C
SIDM00170
Head and Neck Carcinoma
GDSC
LGTPKGS
DEG_SCF_FBW7_1
0.0556
p.R105C
SNU-387
liver
COSMIC
LGTPKGS
DEG_SCF_FBW7_1
0.0556
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Drug responses associated with HMX2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of LGTPKGS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A2RU54
Homeobox protein HMX2
DEG_SCF_FBW7_1
89:95
LGTPKGS
FBXW7
0.9971
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