DegronMD

Uniprot ID: A2RU54

Source protein: Homeobox protein HMX2

Source gene: HMX2

Class: DEG_SCF_FBW7_1

Location: 89:95

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 80.2429

COIL: 0.9357

CONS_SCORE: 0.4348

DSS_SCORE: 0.6265

HELIX: 0.023

FCONS_SCORE: 1.2239

RIG_SCORE: 0.5542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F86L	TCGA-61-2012	OV	TCGA	LGTPKGS	DEG_SCF_FBW7_1	0.25
p.F86L	DO32536	OV	ICGC	LGTPKGS	DEG_SCF_FBW7_1	0.25
p.G96R	TCGA-91-A4BC	LUAD	TCGA	LGTPKGS	DEG_SCF_FBW7_1	0.3056
p.G96R	DO45422	LUAD	ICGC	LGTPKGS	DEG_SCF_FBW7_1	0.3056
p.P87S	TCGA-FR-A3YO	SKCM	TCGA	LGTPKGS	DEG_SCF_FBW7_1	0.2778
p.P87S	DO37419	SKCM	ICGC	LGTPKGS	DEG_SCF_FBW7_1	0.2778
p.P87H	TCGA-GN-A26A	SKCM	TCGA	LGTPKGS	DEG_SCF_FBW7_1	0.2778
p.P87H	DO37861	SKCM	ICGC	LGTPKGS	DEG_SCF_FBW7_1	0.2778
p.K93E	TCGA-IB-7651	PAAD	TCGA	LGTPKGS	DEG_SCF_FBW7_1	0.591
p.K93E	DO46657	PAAD	ICGC	LGTPKGS	DEG_SCF_FBW7_1	0.591
p.G97R	TCGA-RU-A8FL	COAD	TCGA	LGTPKGS	DEG_SCF_FBW7_1	0.2778
p.G97R	DO51733	COAD	ICGC	LGTPKGS	DEG_SCF_FBW7_1	0.2778
p.S95N	SIDM00660	Colorectal Carcinoma	GDSC	LGTPKGS	DEG_SCF_FBW7_1	0.7069
p.S95N	ACH-000985	Colon/Colorectal Cancer	CCLE	LGTPKGS	DEG_SCF_FBW7_1	0.7069
p.S95N	LS-411N	large_intestine	COSMIC	LGTPKGS	DEG_SCF_FBW7_1	0.7069
p.E104K	SIDM00879	Breast Carcinoma	GDSC	LGTPKGS	DEG_SCF_FBW7_1	0.0833
p.E104K	SIDM00930	Osteosarcoma	GDSC	LGTPKGS	DEG_SCF_FBW7_1	0.0833
p.R105C	SIDM01180	Hepatocellular Carcinoma	GDSC	LGTPKGS	DEG_SCF_FBW7_1	0.0556
p.R105C	SIDM00170	Head and Neck Carcinoma	GDSC	LGTPKGS	DEG_SCF_FBW7_1	0.0556
p.R105C	SNU-387	liver	COSMIC	LGTPKGS	DEG_SCF_FBW7_1	0.0556
p.P92R	ACH-001540	Liposarcoma	CCLE	LGTPKGS	DEG_SCF_FBW7_1	0.7512
p.P92S	ACH-001687	Kidney Cancer	CCLE	LGTPKGS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RU54	Homeobox protein HMX2	DEG_SCF_FBW7_1	89:95	LGTPKGS	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons