DegronMD

Uniprot ID: P55265

Source protein: Double-stranded RNA-specific adenosine deaminase

Source gene: ADAR

Class: DEG_SCF_FBW7_2

Location: 165:171

E3 ligase: FBXW7

DEGRON score: 0.9907

ASA_SCORE: 76.2429

COIL: 0.6014

CONS_SCORE: 0.3474

DSS_SCORE: 0.3552

HELIX: 0.3887

FCONS_SCORE: 1.0842

RIG_SCORE: 0.7329

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N173S	TCGA-CN-4734	HNSC	TCGA	LGTPKKE	DEG_SCF_FBW7_2	0.2778
p.S178F	TCGA-EE-A181	SKCM	TCGA	LGTPKKE	DEG_SCF_FBW7_2	0.1389
p.S178F	TCGA-EE-A29V	SKCM	TCGA	LGTPKKE	DEG_SCF_FBW7_2	0.1389
p.R159S	DO44035	BLCA	ICGC	LGTPKKE	DEG_SCF_FBW7_2	0.1667
p.P162S	DO10373	COAD	ICGC	LGTPKKE	DEG_SCF_FBW7_2	0.25
p.L176Q	DO20809	KIRP	ICGC	LGTPKKE	DEG_SCF_FBW7_2	0.1944
p.L169P	DO20870	KIRP	ICGC	LGTPKKE	DEG_SCF_FBW7_2	0.7582
p.R157H	DO38563	STAD	ICGC	LGTPKKE	DEG_SCF_FBW7_2	0.1111
p.R179L	RMG-I	ovary	COSMIC	LGTPKKE	DEG_SCF_FBW7_2	0.1111
p.A173T	LOXIMVI	skin	COSMIC	LGTPKKE	DEG_SCF_FBW7_2	0.2778
p.T161A	TE-4	oesophagus	COSMIC	LGTPKKE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P55265	Double-stranded RNA-specific adenosine deaminase	DEG_SCF_FBW7_2	165:171	LGTPKKE	FBXW7	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons