DegronMD

Uniprot ID: Q12851

Source protein: Mitogen-activated protein kinase kinase kinase kinase 2

Source gene: MAP4K2

Class: DEG_SCF_FBW7_2

Location: 294:300

E3 ligase: FBXW7

DEGRON score: 0.9811

ASA_SCORE: 81.8143

COIL: 0.8804

CONS_SCORE: 0.3115

DSS_SCORE: 0.6349

HELIX: 0.09

FCONS_SCORE: 0.7108

RIG_SCORE: 0.6128

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G295W	TCGA-GN-A26C	SKCM	TCGA	LGTPSPE	DEG_SCF_FBW7_2	0.6714
p.G295W	DO37782	SKCM	ICGC	LGTPSPE	DEG_SCF_FBW7_2	0.6714
p.E300K	DO220882	MELA	ICGC	LGTPSPE	DEG_SCF_FBW7_2	0.7022
p.C302R	DO229232	THCA	ICGC	LGTPSPE	DEG_SCF_FBW7_2	0.2778
p.E305G	DO229232	THCA	ICGC	LGTPSPE	DEG_SCF_FBW7_2	0.1944
p.E303Q	SIDM01128	Small Cell Lung Carcinoma	GDSC	LGTPSPE	DEG_SCF_FBW7_2	0.25
p.E303Q	ACH-000767	Lung Cancer	CCLE	LGTPSPE	DEG_SCF_FBW7_2	0.25
p.E303Q	NCI-H526	lung	COSMIC	LGTPSPE	DEG_SCF_FBW7_2	0.25
p.P297A	ACH-001194	Kidney Cancer	CCLE	LGTPSPE	DEG_SCF_FBW7_2	0.7503

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S227L (No)	GDSC	NG-25	0.116
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.R317Q (No)	GDSC	NG-25	0.0133
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.Q269* (No)	GDSC	NG-25	23.9985
SIDM01007	ALL\|lymphoblastic_leukemia	p.P212H (No)	GDSC	NG-25	0.7013
SIDM01174	CESC\|cervix	p.K260N (No)	GDSC	NG-25	84.4059
SIDM00251	STAD\|stomach	p.R484Q (No)	GDSC	NG-25	43.2331
SIDM00251	STAD\|stomach	p.R279W (No)	GDSC	NG-25	43.2331
SIDM00516	SKCM\|melanoma	p.P435S (No)	GDSC	NG-25	4.4617
SIDM01210	LGG\|glioma	p.A339T (No)	GDSC	NG-25	20.2181
SIDM00946	ALL\|T_cell_leukemia	p.L736P (No)	GDSC	NG-25	1.2783
SIDM00946	ALL\|T_cell_leukemia	p.G321D (No)	GDSC	NG-25	1.2783
SIDM00217	COREAD\|large_intestine	p.R786* (No)	GDSC	NG-25	10.2102
SIDM00217	COREAD\|large_intestine	p.R451Q (No)	GDSC	NG-25	10.2102
SIDM00217	COREAD\|large_intestine	p.F272L (No)	GDSC	NG-25	10.2102
SIDM00217	COREAD\|large_intestine	p.C117Y (No)	GDSC	NG-25	10.2102
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.E303Q (Yes)	GDSC	NG-25	21.4992
SIDM00596	UCEC\|endometrium	p.G597C (No)	GDSC	NG-25	91.3081
SIDM00928	BRCA\|breast	p.R279W (No)	GDSC	NG-25	7.1494
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Y76F (No)	GDSC	NG-25	151.6735
SIDM00545	SKCM\|melanoma	p.P175L (No)	GDSC	NG-25	154.1976
SIDM00744	LUAD\|lung_NSCLC_adenocarcinoma	p.G318R (No)	GDSC	NG-25	154.3287
SIDM00537	COREAD\|large_intestine	p.R605Q (No)	GDSC	NG-25	6.5017

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12851	Mitogen-activated protein kinase kinase kinase kinase 2	DEG_SCF_FBW7_2	294:300	LGTPSPE	FBXW7	0.9811	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons