DegronMD

Uniprot ID: Q8TC57

Source protein: Meiosis 1 arrest protein

Source gene: M1AP

Class: LIG_APCC_ABBA_1

Location: 463:468

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8591

ASA_SCORE: 110.2667

COIL: 0.864

CONS_SCORE: 0.2778

DSS_SCORE: 0.6128

HELIX: 0.1153

FCONS_SCORE: 0.8075

RIG_SCORE: 0.6729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R462W	TCGA-06-0876	GBM	TCGA	LHPHWE	LIG_APCC_ABBA_1	0.3056
p.R462W	DO13150	GBM	ICGC	LHPHWE	LIG_APCC_ABBA_1	0.3056
p.S454I	TCGA-37-4130	LUSC	TCGA	LHPHWE	LIG_APCC_ABBA_1	0.0833
p.S454I	DO26490	LUSC	ICGC	LHPHWE	LIG_APCC_ABBA_1	0.0833
p.P465Q	TCGA-78-7146	LUAD	TCGA	LHPHWE	LIG_APCC_ABBA_1	0.7035
p.P465Q	DO23717	LUAD	ICGC	LHPHWE	LIG_APCC_ABBA_1	0.7035
p.A471D	DO229009	LICA	ICGC	LHPHWE	LIG_APCC_ABBA_1	0.25
p.S453T	SIDM01617	Endometrial Carcinoma	GDSC	LHPHWE	LIG_APCC_ABBA_1	0.0556
p.S453T	ACH-000994	Endometrial/Uterine Cancer	CCLE	LHPHWE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TC57	Meiosis 1 arrest protein	LIG_APCC_ABBA_1	463:468	LHPHWE	APC,CDC20,FZR1	0.8591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons